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首页> 外文期刊>BMC Clinical Pathology >The co-expression of functional gastric proteins in dynamic gastric diseases and its clinical significance
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The co-expression of functional gastric proteins in dynamic gastric diseases and its clinical significance

机译：功能性胃蛋白在动态胃病中的共表达及其临床意义

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Background Pepsinogen C (PGC) and mucin1 (MUC1) are important physiologically functional gastric proteins; Mucin2 (MUC2) is an “ectopic” functional protein in intestinal metaplasia of gastric mucosa. We analyzed the co-expression of the above-mentioned three proteins in dynamic gastric diseases {superficial gastritis (SG)-atrophic gastritis (AG)--gastric cancer (GC)} as well as different histological types of gastric cancer in order to find molecular phenotypes of gastric cancer and precancerous disease and further explore the potential co-function of PGC, MUC1 and MUC2 in the occurrence and development of gastric cancer. Methods The SG-AG-GC sequence was 57-57-70 cases in this case–control study, respectively. Different histological types of GC were 28 cases of highly and moderately differentiated aden ocarcinoma (HMDA)、30 of poorly differentiated adenocarcinoma (PDA) and 12 of mucinous adenocarcinoma (MA) or signet ring cell carcinoma (SRCC). PGC, MUC1 and MUC2 expression in situ were detected in all 184 cases using immunohistochemistry. Results Both PGC and MUC1 had a significantly decreased expression in GC than in SG and AG (P?P?P?P? Conclusions Phenotypes of PGC, MUC1 and MUC2 co-expression in dynamic gastric diseases are variable. In SG group it always showed PGC+/MUC1+/MUC2- phenotype and AG group showed two phenotypes (PGC+/MUC1+/MUC2+ and PGC-/MUC1+/MUC2+); the phenotypes in GC group appeared variable but the phenotype of PGC-/MUC1-/MUC2+ may be a predictive biomarker for diagnosing MA or SRCC, or distinguishing histological MA or SRCC from tubular adenocarcinoma accompanied by mucinous secretion or signet ring cell scattered distribution.
机译：背景胃蛋白酶原C（PGC）和粘蛋白1（MUC1）是重要的生理功能胃蛋白;因此，胃蛋白酶是最重要的。 Mucin2（MUC2）是胃黏膜肠上皮化生中的“异位”功能蛋白。我们分析了上述三种蛋白质在动态胃部疾病{浅表性胃炎（SG）-萎缩性胃炎（AG）-胃癌（GC）}以及胃癌的不同组织学类型中的共表达，以发现胃癌和癌前疾病的分子表型，并进一步探索PGC，MUC1和MUC2在胃癌发生和发展中的潜在作用。方法本病例对照研究的SG-AG-GC序列分别为57-57-70例。不同组织学类型的GC分别为28例高，中分化腺癌（HMDA），30例低分化腺癌（PDA）和12例粘液腺癌（MA）或印戒细胞癌（SRCC）。使用免疫组织化学方法在所有184例患者中均检测到PGC，MUC1和MUC2原位表达。结果PGC和MUC1在GC中的表达均显着低于SG和AG（P？P？P？P？）结论动态胃疾病中PGC，MUC1和MUC2共表达的表型是可变的，在SG组中总是表现出PGC + / MUC1 + / MUC2-表型和AG组表现出两种表型（PGC + / MUC1 + / MUC2 +和PGC- / MUC1 + / MUC2 +）; GC组的表型呈现出可变性，但PGC- / MUC1- / MUC2 +的表型可能是可预测的生物标志物，用于诊断MA或SRCC，或将组织学MA或SRCC与肾小管腺癌并发粘液性分泌物或印记性环细胞分散分布相区别。

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