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An fMRI Investigation of the Cortical Network Underlying Detection and Categorization Abilities in Hemianopic Patients

机译：fMRI对血盲患者检测和分类能力基础的皮质网络的研究

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摘要

The current study aims to investigate visual scene perception and its neuro-anatomical correlates for stimuli presented in the central visual field of patients with homonymous hemianopia, and thereby to assess the effect of a right or a left occipital lesion on brain reorganization. Fourteen healthy participants, three left brain damaged (LBD) patients with right homonymous hemianopia and five right brain damaged (RBD) patients with left homonymous hemianopia performed a visual detection task (i.e. “Is there an image on the screen?”) and a categorization task (i.e. “Is it an image of a highway or a city?”) during a block-designed functional magnetic resonance imaging recording session. Cerebral activity analyses of the posterior areas—the occipital lobe in particular—highlighted bi-hemispheric activation during the detection task but more lateralized, left occipital lobe activation during the categorization task in healthy participants. Conversely, in patients, the same network of activity was observed in both tasks. However, LBD patients showed a predominant activation in their right hemisphere (occipital lobe and posterior temporal areas) whereas RBD patients showed a more bilateral activation (in the occipital lobes). Overall, our preliminary findings suggest a specific pattern of cerebral activation depending on the task instruction in healthy participants and cerebral reorganization of the posterior areas following brain injury in hemianopic patients which could depend upon the side of the occipital lesion.
机译：当前的研究旨在调查视觉偏见及其与同形偏盲患者中心视野中呈现的刺激的神经解剖学相关性，从而评估左右枕骨病变对大脑重组的影响。 14名健康参与者，三名右同名偏盲的左脑损伤（LBD）患者和五名左同名偏盲的右脑损伤（RBD）患者执行了视觉检测任务（即“屏幕上是否有图像？”）并进行了分类。块设计的功能性磁共振成像记录会话期间执行任务（即“是公路还是城市的图像？”）。后方区域（尤其是枕叶）的脑活动分析在检测任务期间突出显示了双半球激活，但在健康参与者中，在分类任务期间突出了偏侧的左枕叶激活。相反，在患者中，两项任务均观察到相同的活动网络。然而，LBD患者在其右半球（枕叶和颞后部区域）显示出主要的激活，而RBD患者则在双侧（枕叶）显示出更多的激活。总体而言，我们的初步发现表明，根据健康参与者的任务指导以及偏盲患者脑损伤后脑后部区域的大脑重组，这可能取决于枕骨病变的一侧，具体取决于大脑活动的特定模式。

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  • 来源
    《Brain Topography》 |2013年第2期|264-277|共14页
  • 作者

    Céline Perez; Carole Peyrin; Céline Cavézian; Olivier Coubard; Florent Caetta; Noa Raz; Netta Levin; Gaëlle Doucet; Frédéric Andersson; Michaël Obadia; Olivier Gout; Françoise Héran; Julien Savatovsky; Sylvie Chokron;

  • 作者单位

    Laboratoire de Psychologie et NeuroCognition UMR 5105 CNRS- UPMF">(1);

    Unité Fonctionnelle Vision Cognition Fondation Ophtalmologique Rothschild">(2);

    Laboratoire de Psychologie et NeuroCognition UMR 5105 CNRS- UPMF">(1);

    Unité Fonctionnelle Vision Cognition Fondation Ophtalmologique Rothschild">(2);

    Laboratoire de Psychologie de la Perception UMR 8156 CNRS Université Paris V">(3);

    The Neuropsychological Laboratory CNS-Fed">(4);

    Unité Fonctionnelle Vision Cognition Fondation Ophtalmologique Rothschild">(2);

    Laboratoire de Psychologie de la Perception UMR 8156 CNRS Université Paris V">(3);

    Department of Neurology Hadassah Hebrew-University Hospital">(5);

    Department of Neurology Hadassah Hebrew-University Hospital">(5);

    Departments of Neurology and Neurosurgery Cognitive Neuroscience and Brain Imaging Laboratory Thomas Jefferson University Jefferson Medical College">(6);

    Université F. Rabelais Tours">(7);

    Service de Neurologie Fondation Ophtalmologique Rothschild">(8);

    Service de Neurologie Fondation Ophtalmologique Rothschild">(8);

    Service de neuroradiologie Fondation Ophtalmologique Rothschild">(9);

    Service de neuroradiologie Fondation Ophtalmologique Rothschild">(9);

    Unité Fonctionnelle Vision Cognition Fondation Ophtalmologique Rothschild">(2);

    Laboratoire de Psychologie de la Perception UMR 8156 CNRS Université Paris V">(3);

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  • 正文语种 eng
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  • 关键词

    Hemianopia; Detection; Categorization; Natural scenes; fMRI;

    机译：Hemianopia;检测;分类;自然场景;功能磁共振成像;

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