Nestin expression in astrocytic tumors delineates tumor infiltration

Ryuhei Kitai; Ryosuke Horita; Kazufumi Sato; Kazuhiko Yoshida; Hidetaka Arishima; Yoshifumi Higashino; Norichika Hashimoto; Hiroaki Takeuchi; Toshihiko Kubota; Ken-Ichiro Kikuta

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Nestin expression in astrocytic tumors delineates tumor infiltration

机译：星形细胞肿瘤中巢蛋白的表达描述了肿瘤浸润

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Nestin is an intermediate filament protein expressed in undifferentiated cells during central nervous system development, and glioma is known to be a highly infiltrative tumor. We determined whether nestin was expressed in astrocytic tumors and could identify infiltrating tumor cells. We screened 65 archival, paraffin-embedded adult astrocytic tumors using immunohistochemical staining and computerized overlaid photographs. Normal biopsied brains and metastatic brain tumors were also examined. The intensity of nestin expression corresponded to the tumor grade. All 33 glioblastoma cases showed positive and extensive staining, which was less positive in diffuse astrocytoma. Overlaid images showed that nestin immunostaining delineated tumor invasion into adjacent gray and white matter. Nestin is a useful marker for examining the infiltration of malignant cells into surrounding tissue.

机译：巢蛋白是中枢神经系统发育过程中在未分化细胞中表达的中间丝蛋白，已知神经胶质瘤是高度浸润性肿瘤。我们确定了巢蛋白是否在星形细胞肿瘤中表达，并可以鉴定浸润的肿瘤细胞。我们使用免疫组织化学染色和计算机覆盖的照片筛选了65个档案，石蜡包埋的成人星形细胞肿瘤。还检查了正常的活检脑和转移性脑肿瘤。巢蛋白表达的强度对应于肿瘤等级。所有33例胶质母细胞瘤病例均显示阳性和广泛染色，而弥漫性星形细胞瘤则阳性率较低。重叠图像显示，巢蛋白免疫染色将肿瘤浸润描绘为相邻的灰色和白色物质。巢蛋白是检查恶性细胞向周围组织浸润的有用标志物。

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《Brain Tumor Pathology》 |2010年第1期|p.17-21|共5页
作者
Ryuhei Kitai; Ryosuke Horita; Kazufumi Sato; Kazuhiko Yoshida; Hidetaka Arishima; Yoshifumi Higashino; Norichika Hashimoto; Hiroaki Takeuchi; Toshihiko Kubota; Ken-Ichiro Kikuta;
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Nestin; Glioma; Invasion;

机译：巢蛋白;胶质瘤;侵入;

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1. Nestin expression in astrocytic tumors delineates tumor infiltration. [J] . Kitai R, Horita R, Sato K, Brain tumor pathology . 2010,第1期

机译：星形细胞肿瘤中巢蛋白的表达描述了肿瘤浸润。
2. Comparison of proliferation index between nestin-positive cells and glial fibrillary acidic protein-positive cells in human astrocytic tumors [J] . Yang Lijuan, Wang Xingfu, Chen Yupeng, 中华医学杂志（英文版） . 2014,第002期

机译：星形胶质细胞瘤巢蛋白阳性细胞和胶质纤维酸性蛋白阳性细胞增殖指数的比较
3. Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. [J] . de Groot M, Iyer A, Zurolo E, Epilepsia: Journal of the International League against Epilepsy . 2012,第1期

机译：人星形细胞肿瘤和肿瘤周围组织中ADK的过表达与肿瘤相关的癫痫有关。
4. Predicting Ki67 expression from DCE-MR images of breast tumors using textural kinetic features in tumor habitats [C] . Baishali Chaudhury, Mu Zhou, Hamidreza Farhidzadeh, Conference on medical imaging . 2016

机译：使用肿瘤生境中的纹理动力学特征从乳腺DCE-MR图像预测Ki67％表达
5. Delineation of molecular targets for malignant brain tumors. [D] . Smith, Shane G. 2003

机译：描绘恶性脑肿瘤的分子靶标。
6. Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy [O] . Marjolein de Groot, Anand Iyer, Emanuele Zurolo, -1

机译：人体星形胶质肿瘤和Peritumoral组织的ADK过度表达与肿瘤相关的癫痫有关
7. Table 5.3.a.1 Tumor size and choledochal infiltration Table 5.3.a.2 Tumor size and duodenal infiltration Table 5.3.a.3 Tumor size and serosal infiltration Table 5.3.a.4 Tumor size and retroperitoneal infiltration Table 5.3.a.5 Tumor size and portal venous system infiltration Table 5.3.a.6 Tumor size and arterial infiltration Table 5.3.a.7 Tumor size and peripancreatic nerve plexus infiltration Table 5.3.a.8 Tumor size and other organ infiltration Table 5.3.a.9 Tumor size and JPS T factor Table 5.3.a.10 Tumor size and declared UICC T factor Figure 5.3.a.11 Cumulative survival of the patients with TS1 cancer according to JPS T factor Figure 5.3.a.12 Cumulative survival of the patients with TS1 cancer according to UICC T factor [O] . 2007

机译：表5.3.a.1肿瘤大小和胆固度渗透表5.3.a.2肿瘤大小和十二指肠浸润表5.3.a.3肿瘤大小和浆液浸润表5.3.a.4肿瘤大小和逆床浸润表5.3.a.5肿瘤大小和门静脉系统浸润表5.3.a.6肿瘤大小和动脉浸润表5.3.a.7肿瘤大小和围嘴巴创建神经丛浸润表5.3.a .8肿瘤大小和其他器官浸润表5.3.a.9肿瘤大小和JPS T因子表5.3.a.10肿瘤大小和宣布的UICC T因子图5.3.a.11累积生存根据JPS T因子的患者TS1癌症图5.3.A.12根据UICC T因子累积TS1癌患者的累积存活

Nestin expression in astrocytic tumors delineates tumor infiltration

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