首页> 外文期刊>British Journal of Haematology >Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)
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Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)

机译:苯扎贝特和醋酸甲羟孕酮联合使用对老年人和复发性急性髓细胞性白血病(AML)无血液毒性的疗效

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SummaryAcute myeloid leukaemia (AML) causes life-threatening deficits of functional blood cells that require management using red cell and platelet transfusion and aggressive treatment of neutropenic infections. Current cytotoxic chemotherapy further worsens the problem of reduced haemopoiesis and two-thirds of patients are too frail to tolerate intensive chemotherapy at all. Median survival amongst these patients remains at 4 weeks. One reverted from high risk myelodysplasia and remains transfusion independent after 201 weeks of therapy. Three AML patients gained major haematological improvements for 22–30 weeks; in one, marrow was available to document a partial AML response. Thus, this trial indicates that BaP therapy has potential for treatment of elderly and relapsed AML.
机译:总结急性髓细胞性白血病(AML)导致威胁生命的功能性血细胞缺乏,需要使用红细胞和血小板输注以及积极治疗中性粒细胞减少症进行管理。目前的细胞毒性化学疗法进一步加剧了造血功能降低的问题,三分之二的患者过于虚弱,根本无法耐受强化化学疗法。这些患者的中位生存期维持在4周。一种从高危骨髓增生异常恢复,在治疗201周后仍保持独立于输血状态。 3名AML患者在22–30周内获得了重大的血液学改善。其中之一是,骨髓可用于记录部分AML反应。因此,该试验表明BaP疗法具有治疗老年和复发性AML的潜力。

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