SPecial report Augmented acetylcholine-induced, Rho-mediated Ca~2+ Sensitization of bronchial smooth muscle contraction in Antigen-induced airway hyperresponsive rats

Yoshihiko Chiba; Yuka Takada; Shigeki Miyamoto

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SPecial report Augmented acetylcholine-induced, Rho-mediated Ca~2+ Sensitization of bronchial smooth muscle contraction in Antigen-induced airway hyperresponsive rats

机译：特别报告抗原诱导的气道高反应性大鼠增强乙酰胆碱诱导的，Rho介导的Ca〜2 +对支气管平滑肌收缩的敏感性

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Treatment with acetylcholine (Ach) of a β-escin-permeabilized intrapulmonary bronchial smooth muscle of the rat induced force when the Ca~2+ concentration was clamped at 1 μM. The Ach- induced Ca~2+ sensitization of myofilaments was signifcantly greater in antigen-induced airway hyperresonsive rats than in control rats. The Ach-induced Ca~2+ sensitization was completely blocked by treatment with Clostridium botulinum C3 exoenzyme, an inactivator of Rho family of proteins.

机译：当Ca〜2 +浓度固定在1μM时，用乙酰胆碱（Ach）处理大鼠的β-七叶皂苷通透性肺内支气管平滑肌。抗原诱导的气道高反应性大鼠中，Ach诱导的肌丝Ca〜2 +敏感性明显高于对照组。 Ach诱导的Ca〜2 +致敏作用通过肉毒梭状芽胞杆菌C3外切酶（一种Rho家族蛋白的失活剂）进行了完全阻断。

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来源
《British Journal of Pharmacology》 |1999年第3期|p.597-600|共4页
作者
Yoshihiko Chiba; Yuka Takada; Shigeki Miyamoto;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Asthma; airway hyperresponsiveness; intrapulmonary bronchial smooth muscle;

机译：哮喘;气道反应过度肺内支气管平滑肌;

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专利

1. Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats [J] . Yoshihiko Chiba, Hiroyasu Sakai, Miwa Misawa British Journal of Pharmacology . 2001,第6期

机译：增强的乙酰胆碱诱导的抗原诱导的气道高反应性大鼠支气管平滑肌中RhoA的移位
2. Acetylcholine-induced smooth muscle contraction of intrapulmonary small bronchi is augmented in antigen-induced airway hyperresponsive rats. [J] . Chiba Y, Takada Y, Sakai H, Japanese Journal of Pharmacology . 2000,第2期

机译：在抗原诱导的气道高反应性大鼠中，乙酰胆碱诱导的肺内小支气管平滑肌收缩增加。
3. Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats [J] . Hiroyasu Sakai, Hisao Takeyama, Miwa Misawa, Japanese Journal of Pharmacology . 2000,第2期

机译：乙酰胆碱诱导的肺内小支气管平滑肌收缩在抗原诱导的气道高反应性大鼠中增强。
4. In vitro studies of tobacco dust extract on airway smooth muscle: role of sensitization [C] . E. Neil Schachter, E. Zuskin, Aneal Gadgil Beltwide Cotton Conferences . 2000

机译：烟雾尘埃提取物对气道平滑肌的体外研究：敏感的作用
5. Studies on the growth of smooth muscle from the airways of hyperresponsive rats. [D] . Zacour, Mary Eleanor. 1998

机译：高反应性大鼠气道平滑肌生长的研究。
6. Augmented acetylcholine-induced Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats [O] . Yoshihiko Chiba, Yuka Takada, Shigeki Miyamoto, 1999

机译：抗原诱导的气道高反应性大鼠中增强的乙酰胆碱诱导的Rho介导的支气管平滑肌收缩的Ca2 +敏化
7. Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats [O] . Chiba, Yoshihiko, Takada, Yuka, Miyamoto, Shigeki, 1999

机译：抗原诱导的气道高反应性大鼠中增强的乙酰胆碱诱导的，Rho介导的支气管平滑肌收缩的Ca2 +致敏

SPecial report Augmented acetylcholine-induced, Rho-mediated Ca~2+ Sensitization of bronchial smooth muscle contraction in Antigen-induced airway hyperresponsive rats

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