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首页> 外文期刊>British Medical Journal >The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis
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The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis

机译：Lambeth早期发病（LEO）小组：针对早期精神病专科治疗效果的随机对照试验

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Objective To evaluate the effectiveness of a service for early psychosis. Design Randomised controlled clinical trial. Setting Community mental health teams in one London borough. Participants 144 people aged 16-40 years presenting to mental health services for the first or second time with non-organic, non-affective psychosis. Interventions Assertive outreach with evidence based biopsychosocial interventions (specialised care group) and standard care (control group) delivered by community mental health teams. Primary outcome measures Rates of relapse and readmission to hospital. Results Compared with patients in the standard care group, those in the specialised care group were less likely to relapse (odds ratio 0.46, 95% confidence interval 0.22 to 0.97), were readmitted fewer times (P 0.39, 0.10 to 0.68), and were less likely to drop out of the study (odds ratio 0.35, 0.15 to 0.81). When rates were adjusted for sex, previous psychotic episode, and ethnicity, the difference in relapse was no longer significant (odds ratio 0.55, 0.24 to 1.26); only total number of readmissions (P 0.36, 0.04 to 0.66) and dropout rates (P 0.28, 0.12 to 0.73) remained significant. Conclusions Limited evidence shows that a team delivering specialised care for patients with early psychosis is superior to standard care for maintaining contact with professionals and for reducing readmissions to hospital. No firm conclusions can, however, be drawn owing to the modest sample size.
机译：目的评估早期精神病服务的有效性。设计随机对照临床试验。在伦敦一个区建立社区精神卫生小组。参与者144例16-40岁的患者首次或第二次出现非有机，非情感性精神病的心理健康服务。干预措施由社区精神卫生团队提供基于证据的生物心理社会干预措施（专业护理组）和标准护理（对照组）的主动外展活动。主要结局指标复发率和再次入院率。结果与标准治疗组相比，专科治疗组复发的可能性较小（赔率比为0.46，95％置信区间为0.22至0.97），再次入院的次数较少（P为0.39，0.10至0.68），且退出研究的可能性较小（赔率比为0.35，0.15至0.81）。调整性别，先前精神病发作和种族的发生率后，复发的差异不再显着（优势比0.55，0.24至1.26）；只有重新入学的总数（P 0.36，0.04至0.66）和辍学率（P 0.28，0.12至0.73）仍然很重要。结论有限的证据表明，为早期精神病患者提供专业护理的团队在保持与专业人员的联系并减少再次住院方面优于标准护理。但是，由于样本量有限，无法得出确切结论。

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