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首页> 外文期刊>World Journal of Gastroenterology >Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases
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Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases

机译：埃及慢性肝病儿童骨骼更新的生化指标的临床益处

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AIM: To investigate the association between serum insulin-like growth factor 1 (IGF-1), osteocalcin, and parathyroid hormone (PTH) levels with the etiology and clinical condition of patients with chronic liver disease. METHODS: Eighty children with hepatocellular damage were divided into 3 groups according to the etiology of disease infection: bilharziasis (9 patients), hepatitis B virus (HBV, 12 patients) and hepatitis C virus (HCV, 29 patients). The Child score index was found as A in 24 patients, B in 22 patients, C in 4 patients. Thirty healthy children served as control group. HBsAg, HBcAbIgM, HBcAbIgG, and anti-HCV were detected using ELISA technique. HCV-RNA was measured by reverse transcription polymerase chain reaction (RT-PCR). Anti-bilharzial antibodies were detected by indirect haem-agglutination test. Liver function tests were performed using autoanalyser. Serum IGF-1, osteocalcin and PTH levels were measured by ELISA technique. Abdominal ultrasonography was also conducted. RESULTS: Serum IGF-1 level was significantly lower in all patient groups with liver diseases, while serum osteocalcin and PTH levels were significantly elevated in patients with HBV and HCV infections compared with the control group. Serum osteocalcin and PTH concentrations were measured with the severity of liver disease from Child A to C. Child A patients unexpectedly showed significantly reduced IGF-1 levels in comparison to patients staged as Child B or C. Serum osteocalcin level was negatively correlated with albumin (14.7 ± 0.54 vs 3.6 ± 0.10, P < 0.05), while that for PTH was positively correlated with total protein (70.1 ± 2.17 vs 6.7 ± 0.10, P < 0.05) in patients with HCV infection. CONCLUSION: Low serum IGF-1 level seems to play a critical role in the bone loss in patients with chronic liver disease. Elevated biochemical markers of bone remodeling suggest high-turnover in patients with viral infection and reflect severity of the clinical stage.
机译：目的：探讨血清胰岛素样生长因子1（IGF-1），骨钙素和甲状旁腺激素（PTH）水平与慢性肝病患者的病因和临床状况之间的关系。方法：将80例肝细胞损伤患儿按疾病感染的病因分为三组：胆道感染（9例），乙肝病毒（HBV，12例）和丙肝病毒（HCV，29例）。儿童得分指数被发现为24例患者为A，22例患者为B，4例患者为C。 30例健康儿童作为对照组。使用ELISA技术检测HBsAg，HBcAbIgM，HBcAbIgG和抗HCV。 HCV-RNA通过逆转录聚合酶链反应（RT-PCR）进行测量。通过间接血红素凝集试验检测抗胆道管抗体。使用自动分析仪进行肝功能测试。 ELISA法检测血清IGF-1，骨钙素和PTH水平。还进行了腹部超声检查。结果：与对照组相比，所有肝病患者组的血清IGF-1水平均显着降低，而HBV和HCV感染患者的血清骨钙素和PTH水平显着升高。测量了从儿童A到儿童C的肝病严重程度的血清骨钙素和PTH浓度。与以儿童B或C分期的患者相比，儿童A的患者出乎意料地显示出IGF-1水平显着降低。血清骨钙素水平与白蛋白呈负相关（ HCV感染患者的PTH与总蛋白呈正相关（14.7±0.54 vs 3.6±0.10，P <0.05），P <0.05）。结论：血清IGF-1的低水平似乎在慢性肝病患者的骨丢失中起关键作用。骨重塑的生化标记升高表明病毒感染患者的高周转率并反映了临床阶段的严重性。

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