Towards a multiscale model of colorectal cancer

Ingeborg MM van Leeuwen; Carina M Edwards; Mohammad Ilyas; Helen M Byrne

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Towards a multiscale model of colorectal cancer

机译：建立多尺度结直肠癌模型

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Colorectal cancer (CRC) is one of the best characterised cancers, with extensive data documenting the sequential gene mutations that underlie its development. Complementary datasets are also being generated describing changes in protein and RNA expression, tumour biology and clinical outcome. Both the quantity and the variety of information are inexorably increasing and there is now an accompanying need to integrate these highly disparate datasets. In this article we aim to explain why we believe that mathematical modelling represents a natural tool or language with which to integrate these data and, in so doing, to provide insight into CRC.

机译：结直肠癌（CRC）是特征最明确的癌症之一，大量数据证明了其发展背后的连续基因突变。还生成了补充数据集，描述了蛋白质和RNA表达，肿瘤生物学和临床结果的变化。信息的数量和种类都无可避免地增加了，现在伴随着整合这些高度不同的数据集的需求。在本文中，我们旨在解释为什么我们认为数学建模代表了一种自然的工具或语言，可以使用这些工具或语言来集成这些数据，并以此来深入了解CRC。

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来源
《World Journal of Gastroenterology》 |2007年第9期|p.1399-1407|共9页
作者
Ingeborg MM van Leeuwen; Carina M Edwards; Mohammad Ilyas; Helen M Byrne;
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作者单位

Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
intestinal epithelium; crypt fission; APC mutations; mathematical modelling; stem cell niche; wnt signalling;

机译：肠上皮;隐窝裂变;APC突变;数学建模;干细胞小生境;wnt信号;

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1. Multiscale Model of Colorectal Cancer Using the Cellular Potts Framework [J] . James M. Osborne Cancer Informatics . 2015,第Supplaa4期

机译：使用细胞Potts框架的大肠癌多尺度模型
2. A Model of Risk of Colorectal Cancer Tested between Studies: Building Robust Machine Learning Models for Colorectal Cancer Risk Prediction [J] . Nartowt B., Hart G. R., Muhammad W., International Journal of Radiation Oncology, Biology, Physics . 2019,第1Suppla期

机译：研究中测试的结直肠癌风险模型：建立结直肠癌风险预测的强大机器学习模型
3. Comparison of Different Colorectal Cancer With Liver Metastases Models Using Six Colorectal Cancer Cell Lines [J] . Yuting Xu, Lin Zhang, Qingling Wang, Pathology oncology research: POR . 2020,第4期

机译：用六种结直肠癌细胞系比较肝转移模型的不同结肠直肠癌
4. Modelling multiscale aspects of colorectal cancer [C] . Ingeborg M. M. van Leeuwen, Helen M. Byrne, Matthew D. Johnston, International Conference on Mathematical Biology . 2008

机译：建模结直肠癌的多尺度方面
5. Evaluation of the accuracy of quantitative models in predicting Lynch syndrome (hereditary nonpolyposis colorectal cancer with defective DNA mismatch repair) mutations in a population-based sample of early-onset colorectal cancer patients [D] . Carpiniello, Lauren 2007

机译：在以人群为基础的早发性大肠癌患者样本中预测定量模型预测Lynch综合征（遗传性非息肉病性大肠直肠癌，DNA失配修复缺陷）的准确性
6. Towards a multiscale model of colorectal cancer [O] . Ingeborg MM van Leeuwen, Carina M Edwards, Mohammad Ilyas, 2007

机译：建立多尺度结直肠癌模型
7. Modelling multiscale aspects of colorectal cancer [O] . van Leeuwen I. M. M., Byrne H. M., Johnston M. D., 2008

机译：对大肠癌的多方面建模
8. Evaluating Test Strategies for Colorectal Cancer Screening-Age to Begin, Age to Stop, and Timing of Screening Intervals: A Decision Analysis of Colorectal Cancer Screening for the U.S. Preventive Services Task Force from the Cancer Intervention and Surveillance Modeling Network (CISNET) [R] . Zauber, A. G., Vogelaar, I. L., Knudsen, A. B., 2009

机译：评估结直肠癌筛查的测试策略 - 开始年龄，年龄停止和筛查间隔的时间：美国癌症干预和监测建模网络（CIsNET）预防性服务工作组的结肠直肠癌筛查决策分析

Towards a multiscale model of colorectal cancer

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