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首页> 外文期刊>World Journal of Gastroenterology >Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples
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Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples

机译：CD147（EMMPRIN）的有用检测对穿刺活检样本中早期肝细胞癌的病理诊断

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AIM: To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS: Twenty-two patients (15 men and 7 women; median age 68 years, range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody, murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition, the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS: The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues, even in tumors less than 15 mm in diameter. The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP. CONCLUSION: CD147 serves potentially as a pathological target for cancer detection of early HCC.
机译：目的：弄清在进行细针穿刺活检的病理性肿瘤样本中CD147（EMMPRIN）的表达是否对早期肝细胞癌（HCC）的病理诊断有用。方法：22例患者（男15例，女7例；中位年龄68岁，范围56-81岁）接受了肝组织活检以诊断HCC。用抗CD147抗体，鼠单克隆抗体12C3（MAb12C3）对22例石蜡包埋的肝活检组织样本进行染色，以进行免疫组织化学分析。进行了CD147的免疫组织化学分析，并比较了肿瘤和非肿瘤组织的染色程度。此外，根据许多临床病理变量比较了肿瘤组织内的染色程度。结果：即使在直径小于15毫米的肿瘤中，肿瘤组织中CD147的染色程度也显着高于非肿瘤组织。在血清AST和γ-GTP值较低的患者的HCC组织标本中，该蛋白的表达显着升高。结论：CD147可能作为早期HCC癌症检测的病理学靶标。

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