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首页> 外文期刊>World Journal of Gastroenterology >Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)
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Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

机译：健康儿童和成人（伊朗东南部）对幽门螺杆菌和CagA的特异性血清免疫球蛋白G

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AIM: To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS: Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method. RESULTS: The seroprevalence of H pylori in adults was significantly higher than that observed in children (67.5% vs 46.6%; P < 0.000003). In children, the seropositivity rate in males (51.9%) was significantly (P < 0.05) higher than that observed in females (41.7%). The prevalence of serum anti-CagA antibody was 72.8% and 67.4% in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P < 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4% vs 66.3%; P = 0.07 and 75.6% vs 54.71%; P < 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6% and 59.57% at age 1-5 years, 46.9% and 75% at age 6-10 years, 54.9% and 79.45% at age 11-15, 59.01% and 83.33% at age 20-30 years, 66.6% and 60.52% at age 31-40 years, 73.46% and 63.88% at age 41-50 years and 75.75% and 60% at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P < 0.001). are more susceptible to infection with CagA~+ strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.
机译：目的：评估不同年龄段以及健康儿童和成人对幽门螺杆菌和CagA的血清IgG反应。方法：总共招募了386名1-15岁的儿童和200名20-60岁的成人。用ELISA法检测参与者的血清样品中是否存在抗幽门螺杆菌和抗CagA IgG。结果：成人幽门螺杆菌的血清阳性率显着高于儿童（67.5％比46.6％； P <0.000003）。在儿童中，男性的血清阳性率（51.9％）显着（P <0.05）高于女性（41.7％）。在感染的儿童和成人中，血清抗CagA抗体的患病率分别为72.8％和67.4％。与成人相比，儿童中血清抗CagA抗体的平均滴度明显更高（64.1 Uarb / mL对30.7； P <0.03）。在受感染的儿童和成人中，男性血清抗CagA抗体的患病率高于女性（分别为78.4％比66.3％； P = 0.07和75.6％比54.71％； P <0.04）。抗H幽门螺杆菌和抗CagA抗体的年龄特异性患病率（在感染受试者中）在1-5岁时分别为37.6％和59.57％，在6-10岁时分别为46.9％和75％，54.9％和79.45％在11-15岁时，在20-30岁时为59.01％和83.33％，在31-40岁时为66.6％和60.52％，在41-50岁时为73.46％和63.88％，在51岁时为75.75％和60％ -60年，抗CagA抗体的平均滴度分别为75.94、63.32、57.11、52.06、23.62、21.52和21.80 Uarb / mL。各年龄组的平均血清抗CagA抗体之间存在显着差异（P <0.001）。与雌性相比，CagA〜+菌株更易感染。抗CagA抗体的血清阳性率随年龄增加而增加，直至30岁，然后下降。还发现，随着年龄的增长，对CagA的IgG应答强度会降低。

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