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Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C

机译:慢性丙型肝炎患者IFN-α和利巴韦林治疗的眼内并发症

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摘要

We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs.
机译:我们报告了八名丙型肝炎病毒(HCV)感染患者的干扰素-α(IFN-α)治疗期间发生的严重炎症和血管性眼内疾病。这些事件包括3例Vogt-Koyanagi-Harada样(VKH)病(胰腺炎,视网膜脱离,耳和脑膜脱离以及皮肤和头发变化的关联),2例视网膜中央静脉阻塞,1例视网膜中央动脉疾病闭塞,严重高血压视网膜病变1例,双侧缺血性视神经病变伴有严重视力障碍1例。这种严重的眼科并发症很少见,需要对接受IFN-α治疗的HCV感染患者进行密切随访,并进行眼科监测(如果出现任何眼部表现)。

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