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首页> 外文期刊>World Journal of Gastroenterology >Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer.
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Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer.

机译：奥美拉唑维持疗法可防止十二指肠溃疡手术后复发性溃疡出血。

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摘要

AIM: To evaluate the omeprazole maintenance therapy in patients with recurrent ulcer bleeding after surgery for duodenal ulcer. METHODS: We studied 15 consecutive patients with recurrent ulcer bleeding after surgery for duodenal ulcer. Omeprazole (20 mg/d) maintenance therapy was given after ulcer healing. In addition to clinical follow-up, ambulatory 24-h gastric pH assay was performed before and during omeprazole therapy in those patients and controls with previous duodenal ulcer surgery but no ulcer recurrence. RESULTS: All the 15 ulcers were healed after being treated with omeprazole (40 mg/d) for 2 mo. Eleven patients with two (1-9) episodes of recurrent ulcer bleeding completed the follow-up (43, 12-72 mo). None of them had a bleeding episode while on omeprazole. One patient discontinued the therapy and had recurrent bleeding. The median 24-h fraction time of gastric pH<4 in patients was 80, 46-95%, and was reduced to 32, 13-70% by omeprazole (P=0.002). CONCLUSION: Long-term maintenance therapy with omeprazole (20 mg/day) is effective in preventing recurrent ulcer bleeding.
机译：目的：评价十二指肠溃疡术后复发性溃疡出血患者的奥美拉唑维持治疗。方法：我们研究了十二指肠溃疡手术后连续溃疡复发出血的15例患者。溃疡愈合后给予奥美拉唑（20 mg / d）维持治疗。除临床随访外，在先前进行十二指肠溃疡手术但无溃疡复发的奥美拉唑治疗之前和期间，在奥美拉唑治疗之前和期间进行了动态24小时胃pH测定。结果：用奥美拉唑（40 mg / d）治疗2个月后，所有15例溃疡均were愈。 11例两次（1-9）复发性溃疡出血的患者完成了随访（43，12-72 mo）。在使用奥美拉唑时，他们都没有出血事件。一名患者停止治疗并再次出血。患者胃内pH <4的24小时中位时间为80％，46％至95％，而奥美拉唑降低至32％，13％至70％（P = 0.002）。结论：奥美拉唑（20毫克/天）的长期维持治疗可有效预防溃疡复发性出血。

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