• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions.
【24h】

Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions.

机译：环氧合酶-2的表达与癌前和恶性胆囊病变中的p53积累有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To examine the relationship between cyclooxygenase-2 (COX-2) overexpression and p53 accumulation in gallbladder carcinoma and its precursor lesions. METHODS: Sixty-eight gallbladder tissue samples comprising 14 cases of normal gallblader epithelium, 27 cases of dysplasia (11 low-grade dyplasia and 16 high-grade dysplasia) and 27 adenocarcinomas were evaluated by immunohistochemistry for COX-2 expression and p53 accumulation. The relationship among COX-2 expression, p53 accumulation and clinicopathological characteristics was analysed. RESULTS: COX-2 was expressed in 14.3% of normal gallbladder epithelium, 70.3% of dysplastic epite hlium, and 59.2% of adenocarcinomas. When divided into low- and high-grade dysplasia, COX-2 was positive in 5 (45.4%) cases of low-grade and 14 (87.5%) of high-grade dysplasia (P = 0.019). Accumulation of p53 was detected in 5 (31.2%) cases of high-grade dysplasia and in 13 (48.1%) of carcinomas. No p53 accumulation was found in normal epithelium or low-grade dysplasia. COX-2 overexpression was observed in 17 of 18 (94.4%) cases with p53-accumulation in comparison with 20 (40.0%) out of 50 cases without p53 accumulation (P<0.001). CONCLUSION: The significant differences in COX-2 expression among normal epithelium, low-grade dysplasia and high-grade dysplasia suggest that overexpression of COX-2 enzyme is an early event in gallbladder carcinogenensis. Furthermore, since accumulation of p53 correlates with COX-2 expression, COX-2 overexpression observed in gallbladder high-grade dysplasia and carcinoma might be partly due to the dysfunction of p53.
机译：目的：探讨胆囊癌及其前体病变中环氧合酶-2（COX-2）过表达与p53积累的关系。方法：采用免疫组织化学方法评估了68例胆囊组织样本，包括14例正常胆囊上皮，27例不典型增生（11例低度增生和16例高度不典型增生）和27例腺癌的COX-2表达和p53积累。分析了COX-2表达，p53积累与临床病理特征之间的关系。结果：COX-2在正常胆囊上皮中占14.3％，在异常增生性表皮中占70.3％，在腺癌中占59.2％。分为低度和高度不典型增生时，COX-2在5例（45.4％）低度不典型和14例（87.5％）高度不典型增生中呈阳性（P = 0.019）。在5例（31.2％）高度不典型增生和13例（48.1％）癌中检测到p53的积累。在正常上皮或低度不典型增生中未发现p53积累。在p53蓄积的18例中有17例（94.4％）观察到COX-2过表达，而50例无p53积聚的病例中有20例（40.0％）（P <0.001）。结论：正常上皮，低度异型增生和高度异型增生之间COX-2表达的显着差异表明COX-2酶的过表达是胆囊癌发生的早期事件。此外，由于p53的积累与COX-2的表达相关，因此在胆囊高度异常增生和癌中观察到的COX-2过表达可能部分是由于p53的功能障碍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号