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首页> 外文期刊>World Journal of Gastroenterology >Glutamine dipeptide for parenteral nutrition in abdominal surgery: a meta-analysis of randomized controlled trials.
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Glutamine dipeptide for parenteral nutrition in abdominal surgery: a meta-analysis of randomized controlled trials.

机译：谷氨酰胺二肽用于腹部手术的肠胃外营养：一项随机对照试验的荟萃分析。

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AIM: To assess the clinical and economical validity of glutamine dipeptide supplemented to parenteral nutrition (PN) in patients undergoing abdominal surgery. METHODS: A meta-analysis of all the relevant randomized controlled trials (RCTs) was performed. The trials compared the standard PN and PN supplemented with glutamine dipeptide in abdominal surgery. RCTs were identified from the following electronic databases: the Cochrane Library, MEDLINE, EMBASE and ISI web of knowledge (SCI). The search was undertaken in April 2006. Literature references were checked by computer or hand at the same time. Clinical trials were extracted and evaluated by two reviewers independently. Statistical analysis was performed by RevMan4.2 software from Cochrane Collaboration. A P value of < 0.05 was considered statistically significant. RESULTS: Nine RCTs involving 373 patients were included. The combined results showed that glutamine dipeptide has a positive effect in improving postoperative cumulative nitrogen balance (weighted mean difference (WMD = 8.35, 95% CI [2.98, 13.71], P = 0.002), decreasing postoperative infectious morbidity (OR = 0.24, 95% CI [0.06, 0.93], P = 0.04), shortening the length of hospital stay (WMD= -3.55, 95% CI [-5.26, -1.84], P < 0.00001). No serious adverse effects were found. CONCLUSION: Postoperative PN supplemented with glutamine dipeptide is effective and safe to decrease the infectious rate, reduce the length of hospital stay and improve nitrogen balance in patients undergoing abdominal surgery. Further high quality trials in children and severe patients are required, and mortality and hospital cost should be considered in future RCTs with sufficient size and rigorous design.
机译：目的：评估在进行腹部手术的患者中，谷氨酰胺二肽补充肠胃外营养（PN）的临床和经济有效性。方法：对所有相关随机对照试验（RCT）进行荟萃分析。该试验在腹部手术中比较了标准PN和补充有谷氨酰胺二肽的PN。从以下电子数据库中识别出RCT：Cochrane图书馆，MEDLINE，EMBASE和ISI知识网（SCI）。搜索于2006年4月进行。文献参考文献同时通过计算机或人工检查。提取了临床试验，并由两名评价员独立评估。统计分析由Cochrane Collaboration的RevMan4.2软件执行。 P <0.05被认为具有统计学意义。结果：纳入了涉及373例患者的9项RCT。综合结果表明，谷氨酰胺二肽在改善术后累积氮平衡方面具有积极作用（加权平均差异（WMD = 8.35，95％CI [2.98，13.71]，P = 0.002），降低了术后感染率（OR = 0.24，95） ％CI [0.06，0.93]，P = 0.04），缩短了住院时间（WMD = -3.55，95％CI [-5.26，-1.84]，P <0.00001），未发现严重不良反应。术后补充谷氨酰胺二肽的PN可以有效，安全地降低腹部手术患者的感染率，缩短住院时间并改善氮平衡，还需要在儿童和重症患者中进行进一步的高质量试验，并应提高死亡率和住院费用具有足够的尺寸和严格的设计在将来的RCT中考虑。

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