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首页> 外文期刊>World Journal of Gastroenterology >Determination of optical properties of normal and adenomatous human colon tissues in vitro using integrating sphere techniques
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Determination of optical properties of normal and adenomatous human colon tissues in vitro using integrating sphere techniques

机译：使用积分球技术测定正常和腺瘤性人结肠组织的光学特性

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AIM: The purpose of the present study is to compare the optical properties of normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion in vitro at 476.5, 488, 496.5, 514.5 and 532 nm. We believe these differences in optical properties should help differential diagnosis of human colon tissues by using optical methods. METHODS: In vitro optical properties were investigated for four kinds of tissues: normal human colon mucosa/ submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/ chorion. Tissue samples were taken from 13 human colons (13 adenomatous, 13 normal). From the normal human colons a total of 26 tissue samples, with a mean thickness 13 from muscle layer/chorion), and from the adenomatous human bladders a total of 26 tissue samples, with a mean thickness of 0.40 mm, were used (13 from mucosa/ submucosa and 13 from muscle layer/chorion). The measurements were performed using a double-integrating-sphere setup and the optical properties were assessed from these measurements using the adding-doubling method that was considered reliable. RESULTS: The results of measurement showed that there were significant differences in the absorption coefficients and scattering coefficients between normal and adenomatous human colon mucosa/submucosa at the same wavelength, and there were also significant differences in the two optical parameters between both colon muscle layer/ chorion at the same wavelength. And there were large differences in the anisotropy factors between both colon mucosa/submucosa at the same wavelength, there were also large differences in the anisotropy factors between both colon muscle layer/chorion at the same wavelength. There were large differences in the value ranges of the absorption coefficients, scattering coefficients and anisotropy factors between both colon mucosa/submucosa, and there were also large differences in these value ranges between both colon muscle layer/chorion. There are the same orders of magnitude in the absorption coefficients for four kinds of colon tissues. The scattering coefficients of these tissues exceed the absorption coefficients by at least two orders of magnitude. CONCLUSION: There were large differences in the three optical parameters between normal and adenomatous human colon mucosa/submucosa at the same laser wavelength, and there were also large differences in these parameters between both colon muscle layer/chorion at the same laser wavelength. Large differences in optical parameters indicate that there were large differences in compositions and structures between both colon mucosa/ submucosa, and between both colon muscle layer/chorion. Optical parameters for four kinds of colon tissues are wavelength dependent, and these differences would be useful and helpful in clinical applications of laser and tumors photodynamic therapy (PDT).
机译：目的：本研究的目的是比较正常人结肠粘膜/粘膜下层和肌肉层/绒毛膜的光学特性，以及腺瘤性人结肠粘膜/粘膜下层和肌肉层/绒毛膜的光学特性，分别为476.5、488、496.5、514.5和532纳米。我们认为，光学特性的这些差异应有助于通过光学方法对人结肠组织进行鉴别诊断。方法：对四种组织的体外光学性质进行了研究：正常人结肠粘膜/粘膜下层和肌肉层/绒毛膜，以及腺瘤性人结肠粘膜/粘膜下层和肌肉层/绒毛膜。从13个人类结肠（13个腺瘤，13个正常）中采集组织样本。从正常人结肠中，总共使用了26个组织样本，平均厚度为13（来自肌肉层/绒毛膜），从腺瘤人膀胱中，总共使用了26个组织样本，平均厚度为0.40 mm（从粘膜/粘膜下层和13从肌肉层/绒毛膜）。使用双积分球装置进行测量，并使用被认为可靠的加倍方法从这些测量中评估光学性质。结果：测量结果表明，在相同波长下正常人和腺瘤人结肠粘膜/粘膜下层之间的吸收系数和散射系数存在显着差异，两个结肠肌层/之间的两个光学参数也存在显着差异在相同波长的绒毛膜。在相同波长下，两个结肠粘膜/粘膜下层之间的各向异性因子差异很大，在相同波长下，两个结肠肌层/绒毛膜之间的各向异性因子差异也很大。两个结肠粘膜/粘膜下层之间的吸收系数，散射系数和各向异性因子的取值范围存在较大差异，两个结肠肌肉层/绒毛膜之间的取值范围也存在较大差异。四种结肠组织的吸收系数具有相同数量级。这些组织的散射系数超过吸收系数至少两个数量级。结论：在相同激光波长下，正常和腺瘤性人结肠粘膜/粘膜下层的三个光学参数之间存在较大差异，在相同激光波长下，两个结肠肌层/绒毛膜之间的三个光学参数之间也存在较大差异。光学参数的大差异表明，两个结肠粘膜/粘膜下层之间以及两个结肠肌肉层/绒毛膜之间的成分和结构都有很大差异。四种结肠组织的光学参数与波长有关，这些差异在激光和肿瘤光动力疗法（PDT）的临床应用中将是有用和有帮助的。

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