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Correlation of Chlamydia pneumonias infection with primary biliary cirrhosis

机译：肺炎衣原体感染与原发性胆汁性肝硬化的相关性

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AIM: To evaluate the association between Chlamydia pneumoniae (Cpn) infection and primary biliary cirrhosis (PBC). METHODS: Cpn IgG and IgM were determined by enzyme-linked immunosorbent assay (ELISA) in 41 well-established PBC patients and two race-matched control groups (post-hepatitis cirrhosis, n = 70; healthy controls, n = 57). RESULTS: The mean level and seroprevalence of Cpn IgG in PBC group and post-hepatitis cirrhosis (PHC) group were significantly higher than those in healthy controls (46.8±43.4 RU/mL, 49.5±45.2 RU/mL vs 28.3±32.7 RU/mL; 68.3%, 71.4%, 42.1%, respectively; P < 0.05). There was a remarkably elevated seroprevalence of Cpn IgM in patients with PBC (22.0%) compared to the PHC and healthy control (HC) groups. For the PBC patients versus the HCs, the odds ratios (ORs) of the presence of Cpn IgG and IgM were 2.7 (95% CI 0.9-6.1) and 5.1 (95% CI 1.4-18.5), respectively. Though there was no correlation in the level of Cpn IgG with total IgG in sera of patients with PBC (r= -0.857, P= 0.344 > 0.05), Cpn IgM was related with the abnormally high concentrations of total IgM in PBC group. CONCLUSION: The results of this study do not support the hypothesis that infection with Chlamydia pneumoniae may be a triggering agent or even a causative agent in PBC, but suggest that Chlamydia pneumoniae infection probably contributes to the high level of IgM present in most patients with PBC.
机译：目的：评估肺炎衣原体（Cpn）感染与原发性胆汁性肝硬化（PBC）之间的关系。方法：采用酶联免疫吸附测定法（ELISA）在41例成熟的PBC患者和两个种族匹配的对照组（肝炎后肝硬化，n = 70；健康对照组，n = 57）中测定了Cpn IgG和IgM。结果：PBC组和肝炎后肝硬化（PHC）组中Cpn IgG的平均水平和血清阳性率显着高于健康对照组（46.8±43.4 RU / mL，49.5±45.2 RU / mL和28.3±32.7 RU / mL）。 mL；分别为68.3％，71.4％，42.1％； P ＜0.05）。与PHC和健康对照组（HC）组相比，PBC患者的Cpn IgM血清阳性率显着升高（22.0％）。对于PBC患者与HCs，Cpn IgG和IgM存在的比值比（OR）分别为2.7（95％CI 0.9-6.1）和5.1（95％CI 1.4-18.5）。尽管PBC患者血清中Cpn IgG水平与总IgG无关（r = -0.857，P = 0.344> 0.05），但Cpn IgM与PBC组总IgM浓度异常高有关。结论：本研究结果不支持以下假设：肺炎衣原体感染可能是PBC的触发剂甚至是致病剂，但表明肺炎衣原体感染可能导致大多数PBC患者中存在高水平的IgM。 。

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