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首页> 外文期刊>World Journal of Gastroenterology >Implications of anti-parietal cell antibodies and anti-Helicobacter pylori antibodies in histological gastritis and patient outcome.
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Implications of anti-parietal cell antibodies and anti-Helicobacter pylori antibodies in histological gastritis and patient outcome.

机译：抗壁细胞抗体和幽门螺杆菌抗体在组织学胃炎和患者预后中的意义。

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AIM: To develop a serum or histological marker for early discovery of gastric atrophy or intestinal metaplasia. METHODS: This study enrolled 44 patients with gastric adenocarcinoma, 52 patients with duodenal ulcer, 14 patients with gastric ulcer and 42 consecutive healthy adults as controls. Each patient received an endoscopy and five biopsy samples were obtained. The degrees of histological parameters of gastritis were categorized following the Updated Sydney System. Anti-parietal cell antibodies (APCA) and anti-Helicobacter pylori (H pylori) antibodies (AHPA) were analyzed by immunoassays. H pylori infection was diagnosed by rapid urease test and histological examination. RESULTS: Patients with gastric cancer and gastric ulcer are significantly older than healthy subjects, while also displaying higher frequency of APCA than healthy controls. Patients with positive APCA showed higher scores in gastric atrophy and intestinal metaplasia of corpus than patients with negative APCA. Patients with positive AHPA had higher scores in gastric atrophy, intestinal metaplasia, and gastric inflammation of antrum than those patients with negative AHPA. Elderly patients had greater prevalence rates of APCA. Following multivariant logistic regression analysis, the only significant risk factor for antral atrophy is positive AHPA, while that for corpus atrophy is positive APCA. CONCLUSION: The existence of positive APCA correlates with glandular atrophy in corpus and the presence of positive AHPA correlates with glandular atrophy in antrum. The existence of serum APCA and AHPA betokens glandular atrophy and requires further examination for gastric cancer.
机译：目的：开发血清或组织学标记物，以及早发现胃萎缩或肠上皮化生。方法：本研究纳入44例胃腺癌患者，52例十二指肠溃疡患者，14例胃溃疡患者和42名连续健康成年人作为对照。每个患者接受内窥镜检查并获得五个活检样本。根据更新的悉尼系统对胃炎的组织学参数进行分类。通过免疫分析法分析了抗壁细胞抗体（APCA）和抗幽门螺杆菌（H pylori）抗体（AHPA）。幽门螺杆菌感染通过快速尿素酶检测和组织学检查诊断。结果：患有胃癌和胃溃疡的患者明显比健康受试者大，同时显示的APCA频率也高于健康对照组。 APCA阳性的患者比APCA阴性的患者在胃萎缩和小肠肠上皮化生方面得分更高。 AHPA阳性的患者与AHPA阴性的患者相比，在胃萎缩，肠上皮化生和胃窦炎症方面得分更高。老年患者的APCA患病率更高。经过多变量logistic回归分析，肛门萎缩的唯一重要危险因素是AHPA阳性，而体萎缩的唯一危险因素是APCA阳性。结论：APCA阳性与体腺萎缩相关，而AHPAA阳性与胃窦腺萎缩相关。血清APCA和AHPA的存在会引起腺体萎缩，并需要进一步检查胃癌。

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