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首页> 外文期刊>World Journal of Gastroenterology >Evaluation of liver tissue by polymerase chain reaction for hepatitis B virus in patients with negative viremia.
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Evaluation of liver tissue by polymerase chain reaction for hepatitis B virus in patients with negative viremia.

机译：聚合酶链反应评估乙型肝炎病毒阴性病毒血症患者的肝组织。

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AIM: To assess the clinical significance of Hepatitis B virus (HBV) DNA localization in the liver tissue of patients with positive HBsAg and negative viremia.METHODS: HBV virological parameters of 33 HBsAg positive chronic hepatitis patients, including seromarkers and HBV DNA amplification in both sera and liver biopsies, were evaluated.RESULTS: Ten patients had negative viremia and positive HBV DNA in their liver biopsies. Most of them had HBeAg-negative/HBeAb-positive chronic hepatitis. Their liver biochemical and histopathological profiles were different from the viremic patients. Their disease pattern was designated as "hepatitis B in situ".CONCLUSION: Hepatitis B in situ is a consequential entity which can be missed in clinical practice. It is a new clinical pattern of chronic HBV infection that considers HBV in liver biopsy and adds a new indication for antiviral therapy.
机译：目的：评估HBsAg阳性和病毒血症阴性的患者肝组织中乙型肝炎病毒（HBV）DNA定位的临床意义。方法：33例HBsAg阳性慢性肝炎患者的HBV病毒学参数，包括血清标志物和HBV DNA扩增结果：10例肝活检中病毒血症阴性且HBV DNA阳性。他们大多数患有HBeAg阴性/ HBeAb阳性的慢性肝炎。他们的肝脏生化和组织病理学特征与病毒血症患者不同。他们的疾病模式被称为“原位乙型肝炎”。结论：原位乙型肝炎是一个重要的实体，在临床实践中可能会被遗漏。这是一种慢性HBV感染的新临床模式，考虑了肝活检中的HBV并为抗病毒治疗增加了新的指征。

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