• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >Impairment of IFN-α production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma
【24h】

Impairment of IFN-α production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma

机译：丙型肝炎病毒患者的IFN-α生产能力受损和发生肝细胞癌的风险

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To determine the utility of interferon (IFN) -α production capacity in patients with hepatitis C virus (HCV) infection for the measurement of immuno-surveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV infection. METHODS: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC). RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing HCC. CONCLUSION: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC.
机译：目的：通过研究仙台病毒，确定丙型肝炎病毒（HCV）感染患者中干扰素（α）产生能力在测量免疫监视潜力和早期检测肝细胞癌（HCC）中的作用（ HVJ）刺激了HCV感染患者的IFN-α产生能力。方法：在许多HCV感染患者中确定了HVJ刺激的IFN-α产生，并在肝硬化（LC）患者中监测了3年的HCC发生。结果：随着从慢性肝炎（CH）到HCC的肝病发展，IFN-α的生产能力逐渐降低。观察到HCV感染持续时间与IFN-α生产能力受损之间存在显着相关性。在3年内发展为HCC的患者中，IFN-α的产生显着低于未发展为HCC的LC患者。结论：测量LC患者的IFN-α产生可能对早期检测HCC有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号