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首页> 外文期刊>World Journal of Gastroenterology >Determination of chemical composition of gall bladder stones: Basis for treatment strategies in patients from Yaounde, Cameroon
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Determination of chemical composition of gall bladder stones: Basis for treatment strategies in patients from Yaounde, Cameroon

机译：胆囊结石化学成分的测定：喀麦隆雅温得患者的治疗策略基础

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AIM: Gallstone disease is increasing in sub-saharan Africa (SSA). In the west, the majority of stones can be dissolved with bile salts, since the major component is cholesterol. This medical therapy is expensive and not readily accessible to poor populations of SSA. It was therefore necessary to analyze the chemical composition of biliary stones in a group of patients, so as to make the case for introducing bile salt therapy in SSA. METHODS: All patients with symptomatic gallstones were recruited in the study. All stones removed during cholecystectomy were sent to Houston for x-ray diffraction analysis. Data on age, sex, serum cholesterol, and the percentage by weight of cholesterol, calcium carbonate, and amorphous material in each stone was entered into a pre-established proforma. Frequencies of the major components of the stones were determined. RESULTS: Sixteen women and ten men aged between 27 and 73 (mean 44.9) years provided stones for the study. The majority of patients (65.38%) had stones with less than 25% of cholesterol. Amorphous material made up more than 50% and 100% of stones from 16 (61.53%) and 9 (34.61%) patients respectively. CONCLUSION: Cholesterol is present in small amounts in a minority of gallstones in Yaounde. Dissolution of gallstones with bile salts is unlikely to be successful.
机译：目的：撒哈拉以南非洲地区（SSA）胆结石病正在增加。在西方，由于主要成分是胆固醇，大多数结石都可以用胆汁盐溶解。这种药物疗法很昂贵，SSA的贫困人口也不容易获得。因此，有必要分析一组患者的胆汁结石的化学成分，以为在SSA中引入胆盐疗法提供依据。方法：本研究招募了所有有症状的胆结石患者。胆囊切除术中所有结石均送至休斯顿进行X射线衍射分析。将有关每个石头中的年龄，性别，血清胆固醇以及胆固醇，碳酸钙和无定形物质的重量百分比的数据输入到预先建立的形式表中。确定了宝石主要成分的频率。结果：年龄在27至73岁（平均44.9岁）之间的16位女性和10位男性为研究提供了结石。大多数患者（65.38％）的胆固醇结石少于25％。 16位患者（61.53％）和9位患者（34.61％）的无定形物质分别占结石的50％和100％以上。结论：雅温得的少数胆结石中胆固醇含量较低。用胆汁盐溶解胆结石不太可能成功。

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