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首页> 外文期刊>World Journal of Gastroenterology >Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage, histopathological grade of malignancy and clinical features
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Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage, histopathological grade of malignancy and clinical features

机译：大肠癌患者血清中v5和v6 CD44剪接变体的水平与pT分期，恶性组织病理学分级和临床特征无关

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摘要

AIM: This study was designed to compare the levels of v5 and v6 splice variants of CD44 evaluated using ELISA test in the serum of patients with colorectal cancer in different stages of progression of the disease estimated in pT stage according to WHO score, histopathological grade of malignancy and some clinicopathological features. METHODS: The serum obtained from 114 persons with colorectal adenocarcinomas was examined using ELISA method. pT stage and grade of malignancy of the tumour were examined in formalin fixed and paraffin embedded materials obtained during operation. RESULTS: Only the level of CD44 v5 in the serum of patients before operation with G2 pT4 tumour was lower than that in other probes and the difference was statistically significant. We did not find any other correlations between the level of v5 and v6 CD44 variants and other evaluated parameters. CONCLUSION: The level of CD44 v5 and v6 estimated by ELISA test in the serum can not be used as a prognostic factor in colorectal cancer.
机译：目的：本研究旨在根据世界卫生组织（WHO）评分，组织病理学等级，根据pT阶段估计的疾病进展不同阶段在大肠癌患者血清中进行ELISA试验评估的CD44的v5和v6剪接变体水平的比较。恶性肿瘤和某些临床病理特征。方法：采用ELISA法检测114例大肠腺癌患者的血清。在手术期间获得的福尔马林固定和石蜡包埋材料中检查了pT分期和恶性程度。结果：仅G2 pT4肿瘤患者术前血清CD44 v5水平低于其他探针，差异有​​统计学意义。我们在v5和v6 CD44变体的水平与其他评估参数之间没有发现任何其他相关性。结论ELISA法检测血清中CD44 v5和v6水平不能作为大肠癌预后的指标。

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  • 来源
    《World Journal of Gastroenterology》 |2004年第4期|p.583-585|共3页
  • 作者

    Bogdan Zalewski;

  • 作者单位

    Ind Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie st. 24a, 15-276 Bialystok, Poland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
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