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Lack of association between seroprevalence of Helicobacter pylori infection and primary biliary cirrhosis

机译：幽门螺杆菌感染的血清阳性率与原发性胆汁性肝硬化之间缺乏关联

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AIM: To determine the association between seroprevalence of Helicobacter pylori'(Hpylori) infection and primary biliary cirrhosis (PBC). METHODS: In this case-control study, 149 consecutive patients (10 males, 139 females, mean age 58.2±11 years, range 26-82 years) suffering from PBC and 619 consecutive healthy volunteer blood donors (523 males, 96 females, mean age 47+-5.3 years, range 18-65 years) attending the Hospital Blood Bank and residing in the same area were recruited. A commercial enzyme linked immunosorbent assay was used to detect anti-H pylori (IgG) antibodies in serum. RESULTS: Antibodies to H pylori were present in 78 (52.3%) out of 149 PBC-patients and in 291 (47%) out of 619 volunteers (P = 0.24, OR 1.24, 95% CI 0.85-1.80). In the subjects less than 60 years old, the prevalence of H pylori infection among PBC-patients (40/79) was slightly higher than in controls (50.6% vs 46.2%) P= 0.46, OR = 1.19,95% CI: 0.72-1.95). In those over 60 years, the prevalence of H pylori infection was similar between PBC-patients and controls (54.2% vS 57.8%, P= 0.7, OR 0.86, 95% CI 0.36-2.07). CONCLUSION: There is no association between seroprevalence of H pylori infection and primary biliary cirrhosis.
机译：目的：确定幽门螺杆菌（Hpylori）感染的血清阳性率与原发性胆汁性肝硬化（PBC）之间的关系。方法：在该病例对照研究中，连续患有149例PBC的患者（男性10例，女性139例，平均年龄58.2±11岁，范围26-82岁）和619例健康志愿者连续献血（523例男性，女性96例，平均招募了年龄在47 + -5.3岁之间（年龄在18-65岁之间）就医的医院血库并居住在同一地区。商业酶联免疫吸附试验用于检测血清中的抗H幽门螺杆菌（IgG）抗体。结果：149例PBC患者中有78例（52.3％）感染了幽门螺杆菌，而619例志愿者中有291例（47％）（P = 0.24，或1.24，95％CI 0.85-1.80）。在60岁以下的受试者中，PBC患者中幽门螺杆菌感染的患病率（40/79）略高于对照组（50.6％vs 46.2％）P = 0.46，OR = 1.19,95％CI：0.72 -1.95）。在60岁以上的人群中，PBC患者和对照组的幽门螺杆菌感染率相似（54.2％vs 57.8％，P = 0.7，或0.86，95％CI 0.36-2.07）。结论：幽门螺杆菌感染的血清阳性率与原发性胆汁性肝硬化之间没有关联。

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