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首页> 外文期刊>World Journal of Gastroenterology >TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease
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TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease

机译：韩国献血者和慢性肝病患者的TT病毒和G型肝炎病毒感染

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AIM: To determine the prevalences of TTV and HGV infections among blood donors and patients with chronic liver disease in Korea, to investigate the association of TTV and HGV infections with blood transfusion, and to assess the correlation between TTV and HGV viremia and hepatic damage. METHODS: A total of 391 serum samples were examined in this study. Samples were obtained from healthy blood donors (n=110), hepatitis B surface antigen (HBsAg)-positive donors (n=112), anti-hepatitis C virus (anti-HCV)-positive donors (n=69), patients with type B chronic liver disease (n=81), and patients with type C chronic liver disease (n=19). TTV DNA was detected using the hemi-nested PCR. HGV RNA was tested using RT-PCR. A history of blood transfusion and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also determined. RESULTS: TTV DNA was detected in 8.2 % of healthy blood donors, 16.1 % of HBsAg-positive donors, 20.3 % of anti-HCV-positive donors, 21.0 % of patients with type B chronic liver disease, and 21.1 % of patients with type C chronic liver disease. HGV RNA was detected in 1.8 % of healthy blood donors, 1.8 % of HBsAg-positive donors, 17.4 % of anti-HCV-positive donors, 13.6 % of patients with type B chronic liver disease, and 10.5 % of patients with type C chronic liver disease. The prevalence of TTV and HGV infections in HBV- or HCV-positive donors and patients was significantly higher than in healthy blood donors (P<0.05), except for the detection rate of HGV in HBsAg-positive donors which was the same as for healthy donors. There was a history of transfusion in 66.7 % of TW DNA-positive patients and 76.9 % of HGV RNA-positive patients (P<0.05). No significant increase in serum ALT and AST was detected in the TTV- or HGV-positive donors and patients. CONCLUSION: TTV and HGV infections are more frequently found in donors and patients infected with HBV or HCV than in healthy blood donors. However, there is no significant association between TTV or HGV infections and liver injury.
机译：目的：确定韩国献血者和慢性肝病患者中TTV和HGV感染的患病率，调查TTV和HGV感染与输血的关系，并评估TTV和HGV病毒血症与肝损害之间的相关性。方法：本研究共检查了391个血清样本。样本来自健康献血者（n = 110），乙型肝炎表面抗原（HBsAg）阳性供体（n = 112），抗丙型肝炎病毒（anti-HCV）阳性供体（n = 69）， B型慢性肝病（n = 81）和C型慢性肝病（n = 19）。使用半巢式PCR检测TTV DNA。 HGV RNA使用RT-PCR测试。还确定了输血史和血清丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）的水平。结果：在8.2％的健康献血者，16.1％的HBsAg阳性献血者，20.3％的抗HCV阳性献血者，21.0％的B型慢性肝病患者和21.1％的2型患者中检测到TTV DNA C慢性肝病。在1.8％的健康献血者，1.8％的HBsAg阳性献血者，17.4％的抗HCV阳性献血者，13.6％的B型慢性肝病患者和10.5％的C型慢性患者中检测到HGV RNA肝病。 HBV或HCV阳性供者和患者中TTV和HGV感染的发生率显着高于健康献血者（P <0.05），但HBsAg阳性供者中HGV的检出率与健康人相同捐助者。 TW DNA阳性患者中有66.7％和HGV RNA阳性患者中有76.9％有输血史（P <0.05）。在TTV或HGV阳性供体和患者中未检测到血清ALT和AST显着增加。结论：与健康献血者相比，在献血者和被HBV或HCV感染的患者中更常见TTV和HGV感染。但是，TTV或HGV感染与肝损伤之间没有显着关联。

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