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首页> 外文期刊>World Journal of Gastroenterology >Experimental study on the feasibility and safety of radiofrequency ablation for secondary splenomagely and hypersplenism
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Experimental study on the feasibility and safety of radiofrequency ablation for secondary splenomagely and hypersplenism

机译：射频消融对继发性脾功能亢进的可行性和安全性的实验研究

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AIM: To assess the feasibility and safety of radiofrequency ablation (RFA) in treatment of secondary splenomagely and hypersplenism. METHODS: Sixteen healthy mongrel dogs were randomly divided into two groups, group Ⅰ ( n=4) and group Ⅱ (n=12). Congestive splenomegaly was induced by ligation of splenic vein and its collateral branches in both groups. At the end of 3rd week postoperation, RFA in spleen was performed in group Ⅱ via laparotomy, complications of RFA were observed, CT scan was performed and the spleens were obtained. The radiofrequency (RF) thermal lesions and histopathology of spleen were examined regularly. RESULTS: No complication or death was observed in both groups; CT revealed that the splenomegaly lasted over 2 months after ligation of splenic vein; the segmental RF lesions included hyperintense zone of coagulative necrosis and more extensive peripheral hypointense infarcted zone, the latter was called "bystander effect". The infarcted zone would be absorbed and subsequently disappeared in 4-6 weeks after RFA accompanied with shrinkage of the remnant spleen. The fundamental histopathological changes of splenic lesions caused by RF thermal energy included local coagulative necrosis, peripheral thrombotic infarction zone, subsequent tissue absorption and fibrosis in the zone of thrombotic infarction, the occlusion of vessels in remnant viable spleen, deposition of extensive fibrous protein, and disappearance of congestive splenic sinusoid - "splenic carnification". Those pathologic changes were underline of shrinkage of spleen. CONCLUSION: It is feasible and safe to perform RFA in spleen to treat experimental splenomegaly and hypersplenism. The RFA could be safely performed clinically via laparotomy or laparoscopic procedure while spleen was strictly separated from surrounding organs.
机译：目的：评估射频消融（RFA）治疗继发性脾功能亢进和脾功能亢进的可行性和安全性。方法：将16只健康杂种犬随机分为两组，分别为Ⅰ组（n = 4）和Ⅱ组（n = 12）。两组均因结扎脾静脉及其侧支而诱发充血性脾肿大。术后第3周末，经开腹手术在Ⅱ组进行脾脏RFA检查，观察RFA并发症，行CT扫描，得到脾脏。定期检查射频（RF）热损伤和脾的组织病理学。结果：两组均未发现并发症或死亡。 CT显示脾静脉结扎术后脾肿大持续了2个月以上。分割的RF病变包括凝血坏死的高信号区和周围广泛的低血脑梗塞区，后者被称为“旁观者效应”。梗死区将被吸收，随后在RFA后4-6周消失，伴有残余脾脏萎缩。射频热能引起的脾脏病变的基本组织病理学变化包括局部凝血坏死，周围血栓性梗塞区，随后的组织吸收和血栓性梗塞区的纤维化，残存的活脾中血管闭塞，广泛的纤维蛋白沉积以及充血性脾窦的消失-“脾脏钙化”。这些病理改变是脾脏缩小的重点。结论：对脾脏进行RFA治疗实验性脾肿大和脾功能亢进是可行且安全的。可以通过剖腹术或腹腔镜手术安全地进行RFA，同时将脾脏与周围器官严格分开。

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