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首页> 外文期刊>World Journal of Gastroenterology >hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer
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hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer

机译：hOGG1 Ser326Cys多态性改变了结肠癌的环境危险因素的意义

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AIM: To determine the association of hOGG1 (8-oxoguanine glycosylase I, OGG1) polymorphism of Ser326Cys substitution with colon cancer risk and possible interaction with known environmental risk factors. METHODS: A case-control study with 125 colon cancer cases and 247 controls was conducted. RESULTS: There was no major difference in Ser326Cys genotype distribution between cases and controls. The meat intake tended to increase the odds ratio for colon cancer with an OR of 1.72 (95 % confidence interval; CI=1.12-2.76). Such tendency was more prominent in Cys/Cys carriers (OR=4.31, 95 % CI=1.64-11.48), but meat intake was not a significant risk factor for colon cancer in Ser/Ser or Ser/ Cys carriers. The OR for colon cancer was elevated with marginal significance in smokers who were Cys/Cys carriers (OR=2.75, 95 % CI=1.07-7.53) but not in Ser/Ser or Ser/ Cys carriers. CONCLUSION: These results suggest that the hOGG1 Ser326Cys polymorphism is probably not a major contributor to individual colon cancer susceptibility overall, but the Cys/ Cys genotype may alter the impact of some environmental factors on colon cancer development.
机译：目的：确定Ser326Cys替代的hOGG1（8-氧代鸟嘌呤糖基化酶I，OGG1）多态性与结肠癌风险以及可能与已知环境风险因素的关联。方法：进行了125例结肠癌病例和247例对照的病例对照研究。结果：病例和对照组之间Ser326Cys基因型分布没有重大差异。肉类摄入倾向于以1.72的OR（95％置信区间； CI = 1.12-2.76）增加结肠癌的优势比。这种趋势在Cys / Cys携带者中更为明显（OR = 4.31，95％CI = 1.64-11.48），但是在Ser / Ser或Ser / Cys携带者中，进食肉类并不是结肠癌的重要危险因素。 Cys / Cys携带者（OR = 2.75，95％CI = 1.07-7.53）的吸烟者结肠癌的OR升高，但在Ser / Ser或Ser / Cys携带者中没有升高。结论：这些结果表明，hOGG1 Ser326Cys多态性可能不是导致个体结肠癌易感性的主要因素，但Cys / Cys基因型可能会改变某些环境因素对结肠癌发展的影响。

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