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首页> 外文期刊>World Journal of Gastroenterology >Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment
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Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment

机译：拉米夫定治疗后，乙型肝炎病毒基因型对乙型肝炎e抗原血清转化没有影响

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摘要

AIM: To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue treatment. METHODS: Chronic hepatitis B patients receiving lamivudine followed up for at least 6 months post-treatment were studied. Consecutive treatment-naive patients who were prospectively followed up in the clinic for at least 18 months were studied as controls. HBeAg seroconversion was defined as loss of HBeAg, appearance of anti-Hbe and normalization of alanine aminotransferase for at least 6 months. RESULTS: Thirty-five patients on lamivudine and 96 control patients followed up for 39 (18-49) months were studied. Lamivudine was given for 12 (10-18) months, and patients were followed up for 15 (6-34) months after drug cessation. Genotype B and C HBV were found in 43 and 88 patients and HBeAg seroconversion occurred in 12 (28 %) and 16 (18 %) patients, respectively (P=0.30). There was no difference in HBeAg seroconversion between patients infected by genotype B and C HBV in the control (35 % vs 21 %, P=0.25) and lamivudine-treated (14 % vs 10 %, P=1.00) groups. CONCLUSION: HBeAg seroconversion after treatment 'by lamivudine was not influenced by the HBV genotype.
机译：目的：研究核苷酸类似物治疗后乙型肝炎病毒（HBV）基因型与HBeAg血清转化的关系。方法：对接受拉米夫定治疗的慢性乙型肝炎患者进行至少6个月的随访。研究对象是连续接受过首次治疗且未在诊所接受至少18个月随访的患者。 HBeAg血清转化定义为至少6个月内HBeAg丢失，抗Hbe出现和丙氨酸氨基转移酶正常化。结果：研究了35例拉米夫定患者和96例对照患者，随访39（18-49）个月。拉米夫定治疗12（10-18）个月，戒烟后随访患者15（6-34）个月。基因型B和C型HBV分别见于43例和88例，HBeAg血清转换分别发生于12例（28％）和16例（18％）（P = 0.30）。对照组（35％vs 21％，P = 0.25）和接受拉米夫定治疗（14％vs 10％，P = 1.00）的基因型B和C HBV感染患者之间的HBeAg血清转化没有差异。结论：拉米夫定治疗后HBeAg血清转化不受HBV基因型的影响。

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