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首页> 外文期刊>Bulletin of the National Research Centre >Persistence of the Vinyl Phosphate Insecticide ~(14)C-Dichlorvos in Stored Soybeans and Its Toxicological Significance to Experimental Animals
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Persistence of the Vinyl Phosphate Insecticide ~(14)C-Dichlorvos in Stored Soybeans and Its Toxicological Significance to Experimental Animals

机译：大豆贮藏中磷酸乙烯基酯杀虫剂〜（14）C-敌敌畏的持久性及其对实验动物的毒理学意义

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Soybeans were treated with the recommended dose of dichlorvos insecticide (12.0mg pesticide/kg seeds) and its duplicate (24 mg pesticide/kg seeds) and stored for 7 months under normal local storage conditions. The rate of penetration of the pesticide through the seeds and the percentage of bound residues were apparently not dose dependent. The amount of surface residues decreased with time to 18 % of the applied dose while the amount of extracted and bound residues inside the seeds showed a slow but definite increase with time of storage and reached more than 61% and 9%, respectively, at the end of the experiment. The incomplete recovery of the applied radioactivity by extraction and combustion may be attributed at least to volatilization of the parent substance. Toxicity of the total internal residues of dichlorvos in stored soybeans was studied in mice through a subchronic feeding experiment for three months. The maximum inhibition in plasma and erythrocyte cholinesterase activity was 60% and 52% after the first month, respectively. Blood picture showed a slight decrease in hemoglobin concentration (18%) and red blood cell counts (19%) and a significant decrease (55%) in white blood cell-counts at the end of experimental period. Treated mice suffered from deterioration of hepatic and renal functions as indicated by the obtained results. Percentage increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) reached to about 93, 61, and 20%, respectively as compared with control animals at the end of feeding period. A significant increase in blood urea (65%) was observed whereas creatinine concentration showed only a slight increase (17%) as compared with control group.
机译：大豆用推荐剂量的敌敌畏杀虫剂（12.0mg农药/千克种子）处理，一式两份（24mg农药/千克种子）处理，在正常的本地储存条件下储存7个月。农药穿透种子的速度和结合残留物的百分比显然与剂量无关。随着时间的推移，表面残留物的数量减少到所施用剂量的18％，而种子内部的提取残留物和结合残留物的数量则随着存储时间的增加而缓慢而确定地增加，在储存时分别达到61％和9％以上。实验结束。通过提取和燃烧不能完全恢复所施加的放射性，这至少可以归因于母体物质的挥发。通过亚慢性喂养实验，在小鼠中研究了储存的大豆中敌敌畏总内部残留物的毒性，历时三个月。在第一个月后，血浆和红细胞胆碱酯酶活性的最大抑制分别为60％和52％。血液图片显示，在实验期结束时，血红蛋白浓度略有下降（18％）和红细胞计数（19％），白细胞计数显着下降（55％）。如获得的结果所示，治疗的小鼠肝和肾功能恶化。与喂食期结束时的对照动物相比，丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST）和碱性磷酸酶（ALP）的百分比分别达到了93％，61％和20％。与对照组相比，观察到血尿素显着增加（65％），而肌酐浓度仅显示轻微增加（17％）。

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