• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Bulletin of the National Research Centre >Toxicity of Bound ~(14)C-Dichlorvos Residues in Stored Soybeans and their Bioavailability to Rat
【24h】

Toxicity of Bound ~(14)C-Dichlorvos Residues in Stored Soybeans and their Bioavailability to Rat

机译：大豆中束缚〜（14）C-敌敌畏残留物的毒性及其对大鼠的生物利用度

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The bound residues necessary for this investigation was obtained by treating whole seeds of soybeans with ~(14)C-dichlorvos insecticide at double the recommended dose (24mg insecticide/kg seeds) and stored for 24 weeks. The level of total internal and bound insecticide residues represented 60 and 7.5% of the actual applied dose, respectively. Subchronic feeding experiments on mice for 90 days with a diet containing the bound pesticide residues at a dose 1.7 ppm/day/mouse caused a slight inhibition of both plasma and red blood cells cholinesterase activity. The maximum inhibition was observed after two months and amounted to 29 and 25 %, respectively. On the other hand, the activity of the liver enzymes alanine amino transferase, aspartate amino transferase and alkaline phosphatase showed a low significant increase in the treated groups after three months of experiments compared with the control group. A moderate increase in blood urea concentration and a slight increase in creatinine concentration was observed in the treated groups at the end of the experimental period. All the blood parameters returned to the control values after a one month recovery period. Feeding rats with the soybeans bound residues for 72 hr revealed that these residues were bioavilable. The main excretion route was via the expired air (45%), while the ~(14)C-residues were excreted in urine and feces in nearly equal proportions. The radioactivity detected among various organs accounted to 15%. Chromatographic analysis of urine showed the presence of some free as well as conjugated metabolites of dichlorvos.
机译：通过用〜（14）C-敌敌畏杀虫剂以两倍推荐剂量（24mg杀虫剂/ kg种子）处理大豆的整个种子，获得了该研究所需的结合残留物，并保存了24周。内部和结合的杀虫剂残留总量分别占实际施用剂量的60％和7.5％。在小鼠中以1.7 ppm /天/小鼠的剂量对小鼠进行90 d亚慢性喂养实验，其饮食中含有结合的农药残留，导致血浆和红细胞胆碱酯酶活性均受到轻微抑制。两个月后观察到最大抑制，分别达到29％和25％。另一方面，在三个月的实验后，与对照组相比，治疗组的肝酶丙氨酸氨基转移酶，天冬氨酸氨基转移酶和碱性磷酸酶的活性显示出较低的显着增加。在实验期结束时，在治疗组中观察到血尿素浓度适度增加，肌酐浓度略有增加。一个月的恢复期后，所有血液参数均恢复到控制值。用大豆结合的残留物喂养大鼠72小时后发现，这些残留物具有生物活性。主要排泄途径是通过呼出空气（45％），而〜（14）C残留物以几乎相等的比例从尿液和粪便中排泄。在各个器官之间检测到的放射性占15％。尿液的色谱分析表明敌敌畏存在一些游离的和结合的代谢产物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号