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首页> 外文期刊>Bulletin of the National Research Centre >Bioavailability to Rat and Toxicity of Bound ~(14)C-Pirimiphos-methyl Residues in Stored Soybeans
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Bioavailability to Rat and Toxicity of Bound ~(14)C-Pirimiphos-methyl Residues in Stored Soybeans

机译：对大鼠的生物利用度和储藏大豆中〜（14）C-嘧啶磷甲基残留物的毒性

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摘要

For the preparation of the bound residues necessary for this investigation, whole seeds of soybeans were treated with ~(14)C-pirimiphos-methyl insecticide at a dose of 30 mg/kg and stored for 24 weeks. The level of total internal and bound insecticide residues represented 60% and 4-5% of the actual dose, respectively. Feeding rats with the soybeans-bound residues for 72 hours, revealed that these residues were bioavailable. The main excretion route was the urine (40%) and feces (18%) while a small amount (6%) could be detected in the expired air. About 25% of the administered radioactivity was detected among various organs of the rat, Chromatographic analysis of urine showed the presence of some free as well as conjugated metabolites of pirimiphos-methyl. Subchronic feeding experiments on mice for 90 days with a diet containing the bound pesticide residues at a dose of 1.6 ppm/day/mouse caused no significant symptoms of toxicity during the period of the experiment. Both plasma and erythrocyte cholinesterases suffered a slight inhibition during the first 15 days. The blood picture and liver function enzymes showed no significant differences from control values. A significant increase in the level of blood urea nitrogen was observed whereas creatinine clearance showed only a slight increase as compared with controls.
机译：为了制备该研究所需的结合残基，用〜（14）C-嘧菌磷甲基杀虫剂以30 mg / kg的剂量处理大豆的整个种子，并保存24周。内部和结合的杀虫剂残留总量分别占实际剂量的60％和4-5％。用大豆结合的残留物喂养大鼠72小时后，发现这些残留物具有生物利用度。主要排泄途径是尿液（40％）和粪便（18％），而在呼出的空气中可以检测到少量（6％）。在大鼠的各个器官中检测到约25％的放射活性。尿液的色谱分析表明，存在一些吡咯甲磷的游离和结合代谢物。在小鼠体内进行亚慢性喂养实验90天，其饮食中含有结合的农药残留，剂量为1.6 ppm /天/小鼠，在实验期间未引起明显的毒性症状。在最初的15天中，血浆胆碱酯酶和红细胞胆碱酯酶均受到轻微抑制。血象和肝功能酶与对照值无明显差异。观察到血尿素氮水平显着增加，而肌酐清除率与对照组相比仅略有增加。

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