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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >Toxicological evaluation and bioavailability of (14)C-fenitrothion bound residues on soybeans towards experimental animals.
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Toxicological evaluation and bioavailability of (14)C-fenitrothion bound residues on soybeans towards experimental animals.

机译：大豆上的（14）C-杀nitro硫酮结合残留物对实验动物的毒理学评估和生物利用度。

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摘要

Under local practice of Egyptian conditions, the application of (14)C-fenitrothion on soybeans at a dose of 10mg insecticide/kg grains, led to the formation of 21% of (14)C-bound residues (non-extractable) after 24 weeks of storage. The external residues were 20% and the internal extracts were 55% of the applied dose. Feeding studies on rats revealed that bound residues were bioavailable. After feeding rats for three days with bound (14)C-fenitrothion residues, the main portion of radioactivity was eliminated via expired air (42%), urine (20%) and feces (11.5%). About 15% of the administered radioactivity was distributed among various organs as, liver, kidney, lung, fat, intestine, blood, heart, and brain. Toxicity of bound residues of (14)C-fenitrothion in stored soybeans was studied in mice through feeding experiments for three months at a concentration of 1.9 mg/kg. The maximum inhibition in plasma and erythrocyte cholinesterase activity was observed 22.5%, 18.9% and 8.6%, 9% after one and seven days, respectively. The obtained results showed a slight significant elevation after three months in the activity of liver enzymes alanine amino transferase, aspartate amino transferase and alkaline phosphatase. A moderate increase in blood urea nitrogen and creatinine concentration was observed in the treated groups at the end of the experimental period. The detected levels of albumin and total protein showed no significant compared to the control values, of controlled animals, after three months.
机译：根据埃及当地的实际情况，在大豆上施用（14）​​C-杀/硫磷的剂量为10mg杀虫剂/ kg谷物，导致在24小时后21％（14）C结合的残留物（不可提取）的形成数周的存储空间。外部残留物为所施加剂量的20％，内部提取物为所施加剂量的55％。对大鼠的喂养研究表明，结合的残基具有生物利用度。用绑定的（14）C-杀nitro硫酮残留物喂养大鼠三天后，通过呼出的空气（42％），尿液（20％）和粪便（11.5％）消除了放射性的主要部分。大约15％的放射放射性分布在肝脏，肾脏，肺，脂肪，肠，血液，心脏和大脑等各个器官之间。通过在小鼠中以1.9 mg / kg的浓度进行三个月的喂养实验，研究了（14）C-杀nitro硫磷结合残留物在储存的大豆中的毒性。在第1天和第7天，分别观察到血浆和红细胞胆碱酯酶活性的最大抑制为22.5％，18.9％和8.6％，9％。所获得的结果显示，三个月后，肝酶丙氨酸氨基转移酶，天冬氨酸氨基转移酶和碱性磷酸酶的活性略有升高。在实验期结束时，在治疗组中观察到血液中尿素氮和肌酐浓度的适度增加。三个月后，与对照动物的对照值相比，检测到的白蛋白和总蛋白水平无明显变化。

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