• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell Research >Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo
【24h】

Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo

机译：回到Oridonin的未来：同样，来自草药的化合物在体外和体内均显示出有效的抗白血病作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Traditional Chinese Medicine (TCM) has been widely and successfully used in treating illnesses ranging from inflammation to cancer, and compounds from medicinal herbs and minerals are playing more and more important roles in taming various kinds of diseases, exemplified by artemisinin and arsenic trioxide (ATO). Artemisinin (or Qinghaosu in Chinese) is isolated from a plant called sweet wormwood (Artemisia annua; or Qinghao in Chinese) which has been used as an antipyretic remedy for more than 1500 years in China. Artemisinin has impressive parasiticidal properties in vitro and in vivo, and is now one of the most important class of antimalarial agents. ATO is a common, naturally occurring substance which had been used in China for a long time as a therapeutic agent for some severe diseases with the ancient philosophy of 'treating an evil with a toxic'. In 1990s, ATO was shown to be able to cause partial differentiation at low dose and apoptosis at high concentration of acute promyelocytic leukemia (APL) cells, and induce complete remission in 90% of patients with relapsed or refractory APL. These paradigms suggest that TCM is the treasure house not only for the Chinese people, but also for the whole human beings. It is our responsibility to develop evidence-based therapeutic approaches from TCM for diseases with poor prognosis.
机译：中药（TCM）已被广泛成功地用于治疗从炎症到癌症的各种疾病，而草药和矿物质中的化合物在驯服各种疾病中起着越来越重要的作用，例如青蒿素和三氧化二砷（ATO） ）。青蒿素（或青蒿素）是从一种叫做甜蒿（Artemisia annua；或青蒿）的植物中分离出来的，在中国，这种植物已被用作解热药1500多年了。青蒿素在体外和体内均具有令人印象深刻的杀虫特性，现已成为最重要的一类抗疟药。 ATO是一种常见的天然存在的物质，在中国已经有很长的“用毒治恶”的古老哲学，在中国已经用作某些严重疾病的治疗剂。在1990年代，ATO被证明能够在低剂量下引起部分分化，在高浓度时会引起急性早幼粒细胞白血病（APL）细胞凋亡，并能在90％复发或难治性APL患者中完全缓解。这些范式表明，中医药不仅是中国人民的宝库，而且是全人类的宝库。对于中预后不良的疾病，我们有责任从中医开发循证治疗方法。

著录项

  • 来源
    《Cell Research》 |2007年第4期|p.274-276|共3页
  • 作者

    Guang-Biao Zhou; Sai-Juan Chen; Zhen-Yi Wang; Zhu Chen;

  • 作者单位

    State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号