Autophagy joins the game to regulate NF-κB signaling pathways

Mojgan Djavaheri-Mergny; Patrice Codogno

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Autophagy joins the game to regulate NF-κB signaling pathways

机译：自噬参与游戏调节NF-κB信号通路

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The nuclear factor kappa B (NF-κB) transcription factor coordinates several aspects of innate and adaptive immunity, inflammation, cell survival and proliferation [1, 2]. Dysregulation of the NF-κB pathway has been associated with cancer development and progression as well as with other human diseases including viral infections and a number of inflammatory diseases [1]. NF-κB is formed through the dimerization of 5 subunits, including members of the Rel protein family, namely RelA (p65), c-Rel, RelB, NF-κB 1 (p50 and its precursor p105) and NF-κB2 (p52 and its precursor p100). Two pathways are involved in the activation of NF-κB. In both these pathways, kinase activity and proteasome activity play a major role in freeing NF-κB from cytoplasmic inhibitors to promote its nuclear translo-cation and activation. The classical or canonical pathway is activated by a large range of stimuli (microbial and viral infections, proinflammatory cytokines).

机译：核因子κB（NF-κB）转录因子可协调先天性和适应性免疫，炎症，细胞存活和增殖的多个方面[1、2]。 NF-κB通路的失调与癌症的发展和进程以及其他人类疾病（包括病毒感染和许多炎症性疾病）有关[1]。 NF-κB是通过5个亚基的二聚化形成的，包括Rel蛋白家族的成员，即RelA（p65），c-Rel，RelB，NF-κB1（p50及其前体p105）和NF-κB2（p52和其前身p100）。 NF-κB的激活涉及两个途径。在这两种途径中，激酶活性和蛋白酶体活性在使NF-κB脱离细胞质抑制剂以促进其核转录和活化中起主要作用。经典或经典途径被多种刺激（微生物和病毒感染，促炎细胞因子）激活。

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来源
《Cell Research》 |2007年第7期|576-577|共2页
作者
Mojgan Djavaheri-Mergny; Patrice Codogno;
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作者单位

Institut National de la Sante et de la Recherche Medicate Unite 756 (INSERM U756);

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
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专利

1. Autophagy joins the game to regulate NF-κB signaling pathways [J] . Mojgan Djavaheri-Mergny, Patrice Codogno 细胞研究（英文版） . 2007,第007期

机译：自噬参与游戏调节NF-κB信号通路
2. Autophagy joins the game to regulate NF-KB signaling pathways [J] . Mojgan Djavaheri-Mergny, Patrice Codogno1 Cell research. . 2007,第7期

机译：自噬参与游戏调节NF-KB信号通路
3. Hirsutella sinensis mycelium regulates autophagy of alveolar macrophages via TLR4/NF-κB signaling pathway [J] . Juanhua Fu, Li Lu, Haining Wang, International Journal of Medical Sciences . 2021,第8期

机译：Hirsutella sinensis菌丝体通过TLR4 / NF-κB信号通路调节肺泡巨噬细胞的自噬
4. Activation of the eIF2 alpha/GCN2 signaling pathway through interferon-γ-stimulated Arginine depletion mediated autophagy in bovine mammary epithelial cells [C] . X.J.Xia, B.P.He, YY Li, 4th international symposium on dairy cow nutrition and milk quality proceedings . 2015

机译：牛乳腺上皮细胞中通过干扰素-γ刺激的精氨酸消耗介导的自噬激活eIF2 alpha / GCN2信号通路
5. Analysis of the Role of Autophagy in Dauer Formation and Dauer Recovery Regulated by TGF-beta Signaling Pathway in Caenorhabditis elegans [D] . Ritter, Portia. 2017

机译：自噬在秀丽隐杆线虫中TGF-β信号通路调节Dauer形成和Dauer恢复中的自噬作用分析
6. Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy [O] . Yuxiang Liu, Wenyuan Liu, Ziyuan Zhang, 2021

机译：Yishen胶囊通过调节SIRT1 / NF-κB信号通路来促进podocyte自噬以改善糖尿病肾病
7. Autophagy joins the game to regulate NF-kappaB signaling pathways. [O] . Djavaheri-Mergny, Mojgan, Codogno, Patrice 2007

机译：自噬加入了游戏，以调节NF-κB信号通路。

Autophagy joins the game to regulate NF-κB signaling pathways

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