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首页> 外文期刊>Cell Research >The magic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4
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The magic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4

机译：四大魔力：Oct4，Sox2，Myc和Klf4从体细胞诱导多能干细胞

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摘要

The developmental process from a fertilized egg to a grown adult is programmed with remarkable accuracy. While the genetic information of the fertilized egg and its descendent somatic cells are the same, it is the selective expressions of the same genome that give rise to the 200 or so different cell types in an adult. The differentiated states of these adult cells are maintained epigenetically, presumably through the modification of chromatins and the associated histones. In higher mammals, it was thought that the differentiation process is irreversible until the successful cloning of Dolly [1]. By transferring a nucleus from a fully differentiated cell in the mammary gland, Wilmut and colleagues were able to generate an exact replica of a higher mammal, the Dolly [1]. This work not only demonstrated that the genome of differentiated cells can be reprogrammed into an embryonic state and then to resume a full-fledged developmental process to generate a normal adult, but also rejuvenated the field of animal cloning. The prospect that a somatic cell from a patient may be reprogrammed to the embryonic state and subsequently induced to generate a specific cell type suitable for transplantation therapy has encouraged a new research direction called "therapeutic cloning" [2]. Yet, technical difficulties and ethical concerns associated with "therapeutic cloning" have cast doubts over its eventual success in the clinic.
机译：从受精卵到成年成虫的发育过程的编程精确度很高。尽管受精卵及其后代体细胞的遗传信息是相同的，但同一基因组的选择性表达在成年人中产生了约200种不同的细胞类型。这些成年细胞的分化状态大概是通过染色质和相关组蛋白的修饰而在表观遗传上得以维持。在高等哺乳动物中，人们认为分化过程是不可逆的，直到成功克隆多利[1]为止。通过从乳腺中完全分化的细胞中转移细胞核，威尔穆特和他的同事们能够产生一种高等哺乳动物多莉的精确复制品[1]。这项工作不仅证明分化细胞的基因组可以重新编程为胚胎状态，然后恢复成熟的发育过程以生成正常的成年动物，而且还使动物克隆领域焕发了青春。来自患者的体细胞可以被重新编程为胚胎状态，并随后被诱导产生适合移植治疗的特定细胞类型的前景鼓励了一种新的研究方向，即“治疗性克隆” [2]。然而，与“治疗性克隆”相关的技术难题和伦理问题使人们对其在临床上的最终成功产生了怀疑。

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  • 来源
    《Cell Research》 |2007年第7期|578-580|共3页
  • 作者

    Huayu Qi; Duanqing Pei;

  • 作者单位

    Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

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