Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells.

Young HA; Ortaldo J

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Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells.

机译：细胞因子是调节自然杀伤细胞免疫反应的关键共刺激分子。

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Cytokines are involved in directing the activation of natural killer (NK) cells. NK cells are involved in the recognition of cells that have been altered; thus they do not recognize specific insults to the host, but when activated, are capable of destroying infected cells directly, as well as promoting the recruitment and response of the other components of the immune system by the release of cytokines and chemokines. It is these properties that have made NK cells a critical part of innate immunity and adaptive immunity, and they play a principal role linking innate and adaptive immunity by the recruitment of an adaptive immune response to an innate immune reaction.Cell Research (2006) 16: 20-24 doi:10.1038/sj.cr.7310004; published online 16 January 2006.

机译：细胞因子参与指导自然杀伤（NK）细胞的激活。 NK细胞参与已改变细胞的识别。因此，它们不识别对宿主的特异性侮辱，但在激活后能够直接破坏受感染的细胞，并通过释放细胞因子和趋化因子来促进免疫系统其他成分的募集和应答。正是这些特性使NK细胞成为先天免疫和适应性免疫的关键部分，并且它们通过募集对先天免疫反应的适应性免疫应答而起着将先天和适应性免疫联系起来的主要作用。CellResearch（2006）16 ：20-24 doi：10.1038 / sj.cr.7310004;在线发布于2006年1月16日。

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《Cell Research》 |2006年第1期|P.20-24|共5页
作者
Young HA; Ortaldo J;
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作者单位

1Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Center for Cancer Research, Frederick, MD 21702, USA.;

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Cytokines; Killer Cells; Natural; Immune response; Immunity; 细胞活素类; 杀伤细胞; 天然; 免疫性;

机译：Cytokines;Killer Cells;Natural;Immune response;Immunity;细胞活素类;杀伤细胞;天然;免疫性;

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专利

1. Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells. [J] . Young HA, Ortaldo J Cell research. . 2006,第1期

机译：细胞因子是调节自然杀伤细胞免疫反应的关键共刺激分子。
2. Expression of B7 co-stimulatory molecules by B16 melanoma results in a natural killer cell-dependent local anti-tumour response, but induces T-cell-dependent systemic immunity only against B7-expressing tumours [J] . H Chong, G Hutchinson, IR Hart, British Journal of Cancer . 1998,第8期

机译：B16黑色素瘤表达B7共刺激分子可导致自然杀伤细胞依赖的局部抗肿瘤反应，但仅诱导针对表达B7的肿瘤的T细胞依赖的全身免疫
3. Expression of B7 co-stimulatory molecules by B16 melanoma results in a natural killer cell-dependent local anti-tumour response, but induces T-cell-dependent systemic immunity only against B7-expressing tumours [J] . H Chong, G Hutchinson, IR Hart, British Journal of Cancer . 1998,第8期

机译：B16黑色素瘤表达B7共刺激分子可导致自然杀伤细胞依赖的局部抗肿瘤反应，但仅诱导针对表达B7的肿瘤的T细胞依赖的全身免疫
4. SOCS genes: Critical regulators of cytokine signaling and immune responses [C] . Akihiko Yoshimura, Hitomi Nishinakamura, Hiromi Takaki Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：SOCS基因：细胞因子信号传导和免疫应答的临界调节因素
5. Identification and characterization of the production of chemokines by natural killer cells and investigations into the effects of these cytokines on natural killer cell biology. [D] . Bluman, Eric Michael. 1998

机译：鉴定和表征自然杀伤细胞产生的趋化因子，并研究这些细胞因子对自然杀伤细胞生物学的影响。
6. Expression of B7 co-stimulatory molecules by B16 melanoma results in a natural killer cell-dependent local anti-tumour response but induces T-cell-dependent systemic immunity only against B7-expressing tumours. [O] . H. Chong, G. Hutchinson, I. R. Hart, 1998

机译：B16黑色素瘤表达B7共刺激分子可导致自然杀伤细胞依赖的局部抗肿瘤反应但仅诱导T细胞依赖的全身免疫抵抗表达B7的肿瘤。
7. Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells [O] . Howard A Young, John Ortaldo 2006

机译：细胞因子作为调节天然杀伤细胞的免疫应答的关键共刺激分子
8. Restoration of Immune Surveillance in Lung Cancer by Natural Killer Cells. [R] . Djeu, J. Y. 2017

机译：自然杀伤细胞恢复肺癌免疫监视。

Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells.

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