...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell Research >Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during Xenopus laevis metamorphosis
【24h】

Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during Xenopus laevis metamorphosis

机译：爪蟾变态过程中甲状腺激素受体转录共激活因子的不同表达谱

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The biological effects of thyroid hormone (T_3) are mediated by the thyroid hormone receptor (TR). Amphibian metamorphosis is one of the most dramatic processes that are dependent on T_3. T_3 regulates a series of orchestrated developmental changes, which ultimately result in the conversion of an aquatic herbivorous tadpole to a terrestrial carnivorous frog. T, is presumed to bind to TRs, which in turn recruit coactivators, leading to gene activation. The best-studied coactivators belong to the p160 or SRC family. Members of this family include SRC1/NCoA-1, SRC2/TIF2/GRIP1, and SRC3/pCIP/ACTR/AIB-1/RAC-3/TRAM-1. These SRCs interact directly with liganded TR and function as adapter molecules to recruit other coactivators such as p300/CBP. Here, we studied the expression patterns of these coactivators during various stages of development. Amongst the coactivators cloned in Xenopus laevis, SRC3 was found to be dramatically upregulated during natural and T_3-induced metamorphosis, and SRC2 and p300 are expressed throughout postembryonic development with little change in their expression levels. These results support the view that these coactivators participate in gene regulation by TR during metamorphosis.
机译：甲状腺激素（T_3）的生物学作用由甲状腺激素受体（TR）介导。两栖动物变态是依赖T_3的最剧烈过程之一。 T_3调节一系列精心安排的发育变化，最终导致水生草食性to转化为陆生食肉青蛙。推测T 1与TR结合，TR进而募集共激活因子，导致基因激活。研究最好的辅助激活剂属于p160或SRC系列。该家族的成员包括SRC1 / NCoA-1，SRC2 / TIF2 / GRIP1和SRC3 / pCIP / ACTR / AIB-1 / RAC-3 / TRAM-1。这些SRC与配体TR直接相互作用，并充当衔接子分子来募集其他共激活因子，例如p300 / CBP。在这里，我们研究了这些共激活因子在发育各个阶段的表达模式。在克隆在非洲爪蟾中的共激活因子中，发现SRC3在自然和T_3诱导的变态过程中显着上调，并且SRC2和p300在整个胚胎后发育中表达，其表达水平几乎没有变化。这些结果支持这样的观点，即这些共激活因子在变态过程中参与了TR的基因调控。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号