Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL63'UTR

DING GAN LIU; QIU HONG JIANG; YUN YI WEI; LI SUN; BEI BEI FU; FU KUN ZHAO; QIONG ZHOU

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Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL63'UTR

机译：支持表型逆转的基因表达谱：NF-IL63'UTR抑制肿瘤机制的线索

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摘要

Transfection of cDNA in 3'untranslated region of human nuclear factor for interleukin-6 (NF-IL6 3'UTR) induced tumor suppression in a human hepatoma cell line. cDNA array analysis was used to reveal changes in gene expression profile leading to tumor suppression The results indicate that this suppression was not due to activation of dsRNA-dependent protein kinase, nor to inactivation of oncogenes; rather, all the changes in expression of known genes, induced by NF-IL6 3'UTR cDNA may be ascribed to the suppression of cellular malignancy. Therefore, our results imply that this 3 'untranslated region may have played role of a regulator of gene expression profile.

机译：cDNA在白细胞介素6（NF-IL6 3'UTR）的人类核因子3'非翻译区中的转染诱导了人类肝癌细胞系中肿瘤的抑制。 cDNA阵列分析用于揭示导致肿瘤抑制的基因表达谱的变化。结果表明这种抑制不是由于dsRNA依赖性蛋白激酶的激活，也不是由于致癌基因的失活。相反，由NF-IL6 3'UTR cDNA诱导的已知基因表达的所有变化都可能归因于细胞恶性肿瘤的抑制。因此，我们的结果暗示该3'非翻译区可能已经发挥了基因表达谱调节剂的作用。

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来源
《Cell Research》 |2003年第6期|p.509-514|共6页
作者
DING GAN LIU; QIU HONG JIANG; YUN YI WEI; LI SUN; BEI BEI FU; FU KUN ZHAO; QIONG ZHOU;
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作者单位

State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
cDNA array; NF-IL6; hepatoma; 3 'UTR; tumor suppression;

机译：cDNA阵列;NF-IL6;肝癌;3'UTR;肿瘤抑制;

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专利

1. Gene expression profile favoring phenotypic reversion:a clue for mechanism of tumor suppression by NF-IL6 3'UTR [J] . 细胞研究（英文版） . 2008,第002期

机译：有利于表型回复的基因表达谱：NF-IL6 3'UTR抑制肿瘤机制的线索
2. Gene expression profile favoring phenotypic reversion:a clue for mechanism of tumor suppression by NF-IL6 3'UTR [J] . DING GAN LIU, QIU HONG JIANG, YUN YI WEI, 细胞研究（英文版） . 2003,第006期

机译：有利于表型回复的基因表达谱：NF-IL6 3'UTR抑制肿瘤机制的线索
3. Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors [J] . Iqbal Mahmud, Daiqing Liao Genomics Data . 2015,第2期

机译：基因芯片基因表达谱揭示了I类HDAC选择性苯甲酰肼抑制剂抑制肿瘤的潜在机制
4. Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays [C] . Christine Sers, Oleg I. Tchernitsa, Johannes Zuber, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：基因表达在Ras癌基因转化的细胞系中和使用减法抑制杂交和cDNA阵列的固体瘤
5. Comparing gene expression profiles of cell culture models with profiles of tumor xenografts and patient tumors: Implications for lung and breast cancers. [D] . Creighton, Chad J. 2006

机译：将细胞培养模型的基因表达谱与异种移植瘤和患者肿瘤谱进行比较：对肺癌和乳腺癌的影响。
6. Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors [O] . Iqbal Mahmud, Daiqing Liao 2015

机译：基因芯片基因表达谱揭示了I类HDAC选择性苯甲酰肼抑制剂抑制肿瘤的潜在机制
7. Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL6 3′UTR [O] . Ding Gan LIU, Qiu Hong JIANG, Yun Yi WEI, 2003

机译：基因表达谱配对表型恢复：NF-IL6 3'UTR肿瘤抑制机理的线索

Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL63'UTR

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