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The use of an electrostatic lens to enhance the efficiency of the electrospinning process

机译：使用静电透镜来提高静电纺丝过程的效率

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Electrospun scaffolds manufactured using conventional electrospinning configurations have an intrinsic thickness limitation, due to a charge build-up at the collector. To overcome this limitation, an electrostatic lens has been developed that, at the same relative rate of deposition, focuses the polymer jet onto a smaller area of the collector, resulting in the fabrication of thick scaffolds within a shorter period of time. We also observed that a longer deposition time (up to 13 h, without the intervention of the operator) could be achieved when the electrostatic lens was utilised, compared to 9–10 h with a conventional processing set-up and also showed that fibre fusion was less likely to occur in the modified method. This had a significant impact on the mechanical properties, as the scaffolds obtained with the conventional process had a higher elastic modulus and ultimate stress and strain at short times. However, as the thickness of the scaffolds produced by the conventional electrospinning process increased, a 3-fold decrease in the mechanical properties was observed. This was in contrast to the modified method, which showed a continual increase in mechanical properties, with the properties of the scaffold finally having similar mechanical properties to the scaffolds obtained via the conventional process at longer times. This “focusing” device thus enabled the fabrication of thicker 3-dimensional electrospun scaffolds (of thicknesses up to 3.5 mm), representing an important step towards the production of scaffolds for tissue engineering large defect sites in a multitude of tissues.
机译：由于集电器上电荷的积累，使用常规静电纺丝配置制造的静电纺丝支架具有固有的厚度限制。为了克服该限制，已经开发出一种静电透镜，该静电透镜以相同的相对沉积速率将聚合物射流聚焦到收集器的较小区域上，从而在较短的时间内制造出厚的支架。我们还观察到，使用静电透镜时，与传统工艺设置下的9–10 h相比，使用静电透镜可以实现更长的沉积时间（长达13 h，无需操作员的干预）。修改后的方法不太可能发生。这对机械性能有重大影响，因为用常规方法获得的支架在短时间内具有较高的弹性模量以及极限应力和应变。然而，随着通过常规电纺丝工艺生产的支架的厚度增加，观察到机械性能降低了3倍。这与改进的方法相反，该改进的方法显示出机械性能的连续增加，支架的性能最终具有与通过常规方法在更长的时间获得的支架相似的机械性能。因此，这种“聚焦”装置使得能够制造更厚的3维电纺丝支架（厚度最大为3.5 mm），这是朝着生产用于组织工程化大量组织中的大缺陷部位的支架迈出的重要一步。

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