Discovery and development of N-cadherin antagonists

Orest W. Blaschuk

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Discovery and development of N-cadherin antagonists

机译：N-钙粘蛋白拮抗剂的发现与发展

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This article describes over 20 years of research on antagonists of the cell adhesion molecule, N-cadherin. Four types of antagonists are discussed: synthetic linear peptides, synthetic cyclic peptides, non-peptidyl peptidomimetics of the disulfide linked cyclic peptide N-Ac-CHAVC-NH₂ and monoclonal antibodies directed against the N-cadherin ectodomain. The biological activities of these antagonists are also discussed. In particular, the ability of N-cadherin antagonists to act as anti-cancer drugs is considered.

机译：本文介绍了20多年来对细胞粘附分子N-钙粘着蛋白拮抗剂的研究。讨论了四种类型的拮抗剂：合成线性肽，合成环肽，二硫键连接的环肽N-Ac-CHAVC-NH _{2 的非肽基拟肽和针对N-钙粘蛋白胞外域的单克隆抗体。还讨论了这些拮抗剂的生物学活性。特别地，考虑了N-钙粘蛋白拮抗剂作为抗癌药的能力。}

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《Cell and Tissue Research》 |2012年第2期|p.309-313|共5页
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Orest W. Blaschuk;
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Discovery and development of N-cadherin antagonists

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