Activation of subventricular zone stem cells after neuronal injury

Yongsoo Kim; Francis G. Szele

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Activation of subventricular zone stem cells after neuronal injury

机译：神经元损伤后脑室下区干细胞的活化

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The mammalian subventricular zone (SVZ) has garnered a tremendous amount of attention as a potential source of replacement cells for neuronal injury. This zone is highly neurogenic, harbours stem cells and supports long-distance migration. The general pattern of activation includes increased proliferation, neurogenesis and emigration towards the injury. Intrinsic transcription factors and environmental signalling molecules are rapidly being discovered that may facilitate the induction of these cells to mount appropriate therapeutic responses. The extent of SVZ neurogenesis in humans is controversial. However, tantalizing new data suggest that humans are capable of generating increased numbers of neurons after a variety of diseases.

机译：作为神经元损伤替代细胞的潜在来源，哺乳动物的脑室下区域（SVZ）已引起了极大的关注。该区域具有高度神经源性，具有干细胞并支持远距离迁移。活化的一般模式包括增加的增殖，神经发生和向损伤的迁移。内在转录因子和环境信号分子迅速被发现，可以促进这些细胞的诱导以产生适当的治疗反应。人体中SVZ神经发生的程度是有争议的。但是，令人鼓舞的新数据表明，人类能够在多种疾病后产生更多数量的神经元。

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来源
《Cell and Tissue Research》 |2008年第1期|337-345|共9页
作者
Yongsoo Kim; Francis G. Szele;
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作者单位

Department of Physiology Anatomy and Genetics University of Oxford Le Gros Clark Building South Parks Road Oxford OX1 3QX UK;

Department of Physiology Anatomy and Genetics University of Oxford Le Gros Clark Building South Parks Road Oxford OX1 3QX UK;

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正文语种 eng
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关键词
Subventricular zone; Stem cells; Neurogenesis; Neuronal injury; Mammals; Human;

机译：脑室下区;干细胞;神经发生;神经损伤;哺乳动物;人类;

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专利

1. Activation of subventricular zone stem cells after neuronal injury. [J] . Kim Y, Szele FG Cell and Tissue Research . 2008,第1期

机译：神经元损伤后脑室下区干细胞的活化。
2. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone [J] . López-JuárezA., HowardJ., UllomK., Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2013,第11期

机译：Gsx2控制成人脑室下区神经干细胞的区域特异性激活和损伤诱导的神经发生
3. Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury. [J] . Gleason D, Fallon JH, Guerra M, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2008,第1期

机译：室管膜干细胞被损伤激活后不对称分裂，并将子代转移到脑室下区。
4. Neurotoxic effects of ochratoxin A onto neural stem cells from the subventricular zone in vitro [C] . B. Rocamonde, E.M. Mateo, M. Jiménez, International Conference on Environmental, Industrial and Applied Microbiology . 2014

机译：Ochratoxina在体外脑室区神经干细胞上的神经毒性作用
5. Factors influencing the differentiation and cell cycle properties of the unique neuronal progenitor cells of the neonatal anterior subventricular zone (SVZa). [D] . Coskun, Volkan. 2003

机译：影响新生儿前脑室下区（SVZa）的独特神经元祖细胞分化和细胞周期特性的因素。
6. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone [O] . Alejandro López-Juárez, Jennifer Howard, Kristy Ullom, 2013

机译：Gsx2控制成人脑室下区神经干细胞的区域特异性激活和损伤诱导的神经发生。
7. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone [O] . A. Lopez-Juarez, J. Howard, K. Ullom, 2013

机译：GSX2控制成人子底区中神经干细胞和损伤诱导神经发生的区域特异性活化

Activation of subventricular zone stem cells after neuronal injury

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