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首页> 外文期刊>CEN Case Reports >A distinct lymphocyte distribution in relapse after rituximab for steroid-dependent nephrotic syndrome
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A distinct lymphocyte distribution in relapse after rituximab for steroid-dependent nephrotic syndrome

机译：利妥昔单抗治疗类固醇依赖型肾病综合征后复发中的明显淋巴细胞分布

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摘要

Rituximab (RTX) is a new steroid-sparing therapy for childhood steroid-dependent nephrotic syndrome (NS). However, relapses frequently occur immediately after CD19 recovery. We report the cases of two steroid-dependent NS patients treated with RTX followed by mizoribine (MZB). One patient relapsed, and the other developed proteinuria after CD19 recovery until the MZB was replaced by mycophenolate mofetil. These patients exhibited different lymphocyte phenotypes, with the CD4+/CD8+ profile favoring CD8+ T lymphocytes, while CD3+ HLA-DR-expressing activated T lymphocyte expansion occurred in the relapsed patient. Based on these findings, we suggest that T cell activation may influence outcome and that phenotypic analysis in addition to B cell monitoring may facilitate the detection of NS relapse.
机译：利妥昔单抗（RTX）是一种针对儿童的类固醇依赖性肾病综合征（NS）的新型类固醇疗法。但是，复发经常在CD19恢复后立即发生。我们报告了两名接受RTX继而接受米佐利滨（MZB）治疗的类固醇依赖型NS患者的病例。一名患者复发，另一名患者在CD19恢复后发展为蛋白尿，直到用霉酚酸酯代替MZB。这些患者表现出不同的淋巴细胞表型，其中CD4 + / CD8 +谱有利于CD8 + T淋巴细胞，而复发的患者发生CD3 + HLA-DR表达的活化T淋巴细胞扩增。基于这些发现，我们建议T细胞活化可能会影响预后，并且除了B细胞监测外，表型分析还可能有助于检测NS复发。

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  • 来源
    《CEN Case Reports》 |2013年第1期|1-5|共5页
  • 作者

    Masaki Shimizu; Tadafumi Yokoyama; Sayaka Ishikawa; Kazuyuki Ueno; Kazuhide Ohta; Akihiro Yachie;

  • 作者单位

    Department of Pediatrics School of Medicine Institute of Medical Pharmaceutical and Health Sciences Kanazawa University">(1);

    Department of Pediatrics School of Medicine Institute of Medical Pharmaceutical and Health Sciences Kanazawa University">(1);

    Department of Pediatrics School of Medicine Institute of Medical Pharmaceutical and Health Sciences Kanazawa University">(1);

    Department of Pediatrics School of Medicine Institute of Medical Pharmaceutical and Health Sciences Kanazawa University">(1);

    Department of Pediatrics Kanazawa Medical Center">(2);

    Department of Pediatrics School of Medicine Institute of Medical Pharmaceutical and Health Sciences Kanazawa University">(1);

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  • 正文语种 eng
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  • 关键词

    Rituximab; Nephrotic syndrome; T cell; B cell;

    机译：利妥昔单抗;肾病综合征T细胞B细胞;

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