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The lagged effects of environmentally relevant zinc on non-specific immunity in zebrafish

机译：环境相关锌对斑马鱼非特异性免疫的滞后作用

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摘要

Responses to zinc (Zn) during exposure have well studied but the effects after the exposure are commonly neglected. In the study, non-specific immune response to zinc in blood and spleen of zebrafish was evaluated after exposure. At first, fish were subjected to O (control) and 200 mu g/L zinc (Zn) for 6 weeks. Specific growth rate, survival rate, blood albumin level, and the activities of Cu/Zn-SOD and iNOS were not significantly changed by Zn exposure. Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1 beta tnf-alpha and inos. In the second experiment, zebrafish were transferred to a recovery period for 4 and 8 days. The increased activities of Cu/Zn-SOD and CAT and the up-regulated mRNA levels of nrf2, cat, p65, tnf-alpha, and inos still were observed. In the third experiment, zebrafish from 4 d post-exposure were re-exposed to the high levels of Zn and cadmium (Cd) (600, 1200 mu g/L Zn; 100, 200 mu g/L Cd) for 4 days. 100 mu g/L Cd caused a higher survival rate in the Zn-exposed fish than the control, suggesting Zn pre-exposure might develop the tolerance to Zn and Cd. Although transcriptional levels of sod1, hsf1, hsf2, hsp70, il-6 and il-beta and activity levels of iNOS recovered to the control levels at 4 and 8 d post-exposure, differences in magnitude of responsiveness were observed between normal fish and Zn-exposed fish. Overall, Zn acclimation persisted when fish recovered, which provides a new perspective about Zn toxicology. (C) 2018 Published by Elsevier Ltd.
机译：对锌在暴露过程中的反应进行了充分的研究，但通常忽略了暴露后的影响。在这项研究中，暴露后评估了对斑马鱼血液和脾脏中锌的非特异性免疫反应。首先，对鱼类进行O（对照）和200μg / L锌（Zn）处理6周。锌暴露没有明显改变比生长率，存活率，血白蛋白水平以及Cu / Zn-SOD和iNOS的活性。相反，锌会增加球蛋白和血红蛋白水平，CAT活性以及nrf2，sod1，cat，hsf1，hsp70，p65，il-6，il-1 beta tnf-alpha和inos的mRNA水平。在第二个实验中，将斑马鱼转移到恢复期为4天和8天。仍然观察到Cu / Zn-SOD和CAT的活性增加以及nrf2，cat，p65，tnf-alpha和inos的mRNA上调。在第三个实验中，将暴露后4天的斑马鱼重新暴露于高水平的锌和镉（Cd）（600，1200μg/ L Zn; 100，200μg/ L Cd）4天。 100μg/ L Cd导致锌暴露鱼类的存活率高于对照组，这表明Zn的预暴露可能会提高对Zn和Cd的耐受性。尽管sod1，hsf1，hsf2，hsp70，il-6和il-beta的转录水平以及iNOS的活性水平在暴露后4和8 d恢复到对照水平，但正常鱼和Zn之间的反应强度却存在差异暴露的鱼。总体而言，当鱼类恢复时，锌的适应性仍然存在，这为锌的毒理学提供了新的视角。 （C）2018由Elsevier Ltd.发布

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  • 来源
    《Chemosphere》 |2019年第1期|85-93|共9页
  • 作者

    Si Lan-Fang; Wang Cheng-Cheng; Guo Sai-Nan; Zheng Jia-Lang; Xia Hu;

  • 作者单位

    Zhejiang Ocean Univ, Natl Engn Res Ctr Marine Facil Aquaculture, Zhoushan 316022, Peoples R China;

    Hunan Univ Arts & Sci, Collaborat Innovat Ctr Efficient & Hlth Prod Fish, Key Lab Hlth Aquaculture & Prod Proc Dongting Lak, Zool Key Lab Hunan Higher Educ, Changde 415000, Hunan, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Fish; Zinc; Cadmium; Immunity; Post-exposure;

    机译：鱼;锌;镉;免疫力;接触后;

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