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首页> 外文期刊>Chemosphere >Evaluation of the QuEChERS method for the extraction of Pharmaceuticals and personal care products from drinking-water treatment sludge with determination by UPLC-ESI-MS/MS
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Evaluation of the QuEChERS method for the extraction of Pharmaceuticals and personal care products from drinking-water treatment sludge with determination by UPLC-ESI-MS/MS

机译：用UPLC-ESI-MS / MS测定从饮用水处理污泥中提取药物和个人护理产品的QuEChERS方法的评估

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摘要

A modified version of the QuEChERS method has been evaluated for the determination of 21 pharmaceuticals and 6 personal care products (PPCPs) in drinking-water sludge samples by employing ultra high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The performance of the method was evaluated through linearity, recovery, precision (intra-day), method detection and quantification limits (MDL and MQL) and matrix effect. The calibration curves prepared in acetonitrile and in the matrix extract showed a correlation coefficient ranging from 0.98 to 0.99. MQLs values were on the ng g~(-1) order of magnitude for most compounds. Recoveries between 50% and 93% were reached with RSDs lower than 10% for most compounds. Matrix effect was almost absent with values lower than 16% for 93% of the compounds. By coupling a quick and simple extraction called QuEChERS with the UPLC-MS/MS analysis, a method that is both selective and sensitive was obtained. This methodology was successfully applied to real samples and caffeine and benzophenone-3 were detected in ng g~(-1) levels.
机译：QuEChERS方法的改进版本已通过超高液相色谱-串联质谱法（UPLC-MS / MS）进行了评估，用于测定饮用水污泥样品中的21种药品和6种个人护理产品（PPCP）。通过线性，回收率，精密度（日内），方法检测和定量极限（MDL和MQL）以及基质效应评估了该方法的性能。在乙腈和基质萃取物中制备的校准曲线显示相关系数在0.98至0.99之间。大多数化合物的MQLs值在ng g〜（-1）数量级。大多数化合物的回收率均低于10％，回收率达到50％至93％。对于93％的化合物，几乎没有基质效应，其值低于16％。通过将称为QuEChERS的快速，简单提取与UPLC-MS / MS分析结合起来，获得了一种既选择性又灵敏的方法。该方法已成功应用于实际样品中，并以ng g〜（-1）的水平检测到了咖啡因和二苯甲酮3。

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  • 来源
    《Chemosphere》 |2014年第7期|74-82|共9页
  • 作者

    Maristela B.R. Cerqueira; Juliana R. Guilherme; Sergiane S. Caldas; Manoel L. Martins; Renato Zanella; Ednei G. Primel;

  • 作者单位

    Post-Graduation Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Italia, km 8, s, Rio Grande, Rio Grande do Sul State 96201-900, Brazil;

    Post-Graduation Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Italia, km 8, s, Rio Grande, Rio Grande do Sul State 96201-900, Brazil;

    Post-Graduation Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Italia, km 8, s, Rio Grande, Rio Grande do Sul State 96201-900, Brazil;

    Laboratorio de Analises de Residuos de Pesticidas (LARP), Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul State, Brazil;

    Laboratorio de Analises de Residuos de Pesticidas (LARP), Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul State, Brazil;

    Post-Graduation Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Italia, km 8, s, Rio Grande, Rio Grande do Sul State 96201-900, Brazil;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    UPLC-MS/MS; Drinking-water sludge samples; PPCPs; QuEChERS;

    机译：UPLC-MS / MS;饮用水污泥样品;PPCP;QuEChERS;

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