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首页> 外文期刊>The Chinese-German Journal of Clinical Oncology >Expression and Significance of PTEN in Bladder Transitional Cell Carcinoma
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Expression and Significance of PTEN in Bladder Transitional Cell Carcinoma

机译:PTEN在膀胱移行细胞癌中的表达及其意义

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Objective: To explore the expression of anti-oncogene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods: Using immunohistochemical S-P methods, the expression of PTEN gene was detected in 62 specimens of bladder cancer and 18 specimens of normal bladder tissue. Results: In the 62 bladder cancers, the positive rate of PTEN was 53.2% (33/62). All 18 normal bladder tissues were positive for the PTEN expression. The expression of PTEN was negatively correlated to tumor grades (P < 0.05). Conclusion: The reduced expression of PETN might play an important role in carcinogenesis and progression of bladder cancer. Detection of PTEN might be useful for judgement of tumor development and prognosis.
机译:目的:探讨抗癌基因PTEN在膀胱移行细胞癌中的表达及其临床意义。方法:采用免疫组化S-P方法,在62例膀胱癌和18例正常膀胱组织中检测PTEN基因的表达。结果:在62例膀胱癌中,PTEN阳性率为53.2%(33/62)。所有18个正常膀胱组织的PTEN表达均为阳性。 PTEN的表达与肿瘤等级呈负相关(P <0.05)。结论:PETN表达降低可能在膀胱癌的发生发展中起重要作用。检测PTEN可能有助于判断肿瘤的发展和预后。

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