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Advances in G-protein coupled receptor research and related bioinformatics study

机译：G蛋白偶联受体研究及相关生物信息学研究进展

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摘要

G-protein coupled receptor (GPCR) is one of the most important protein families for drug target. GPCR agonists and antagonists occupy approximately one third of the world small molecule drug market. Much effort has been invested in GPCR study by both academic institutions and pharmaceutical industries. With seven-transmembrane domains, GPCR plays significant roles in intercellular signal transduction and is involved in a variety of biological pathways. With the availability of sequence data of human and other mammalian genomes, as well as their expressed sequence tag (EST) data, the bioinformatics and genomics approaches can be applied to identifying novel GPCR in the post genomic era. Deorphanizing GPCR or matching ligands with GPCR greatly facilitates target validation process and automatically provides a possible compound screening assay. Similarly, bioinformatics data mining approach could also be applied to the identification of GPCR peptide or protein ligands. Here we give a general review of recent advances in the study of GPCR structure, function, as well as GPCR and ligand identification with the emphasis on the bioinformatics database mining of GPCR and their peptide or protein ligands.
机译：G蛋白偶联受体（GPCR）是药物靶标中最重要的蛋白质家族之一。 GPCR激动剂和拮抗剂约占世界小分子药物市场的三分之一。学术机构和制药行业都在GPCR研究上投入了大量精力。 GPCR具有七个跨膜结构域，在细胞间信号转导中起重要作用，并参与多种生物学途径。利用人类和其他哺乳动物基因组的序列数据及其表达的序列标签（EST）数据，生物信息学和基因组学方法可用于鉴定后基因组时代的新型GPCR。将GPCR脱色或与GPCR匹配的配体大大简化了靶标验证过程，并自动提供了可能的化合物筛选方法。同样，生物信息学数据挖掘方法也可用于鉴定GPCR肽或蛋白质配体。在这里，我们对GPCR的结构，功能以及GPCR和配体鉴定的研究进展进行了综述，重点是对GPCR及其肽或蛋白质配体的生物信息学数据库的挖掘。

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  • 来源
    《Chinese science bulletin》 |2003年第6期|p. 511-516|共6页
  • 作者

    Yin Yanbin; Luo Jingchu; Jiang Ying;

  • 作者单位

    College of Life Sciences, National Laboratory of Plant Genetic Engineering and Protein Engineering, Center of Bioinformatics, Peking University, Beijing 100871, China;

    College of Life Sciences, National Laboratory of Plant Genetic Engineering and Protein Engineering, Center of Bioinformatics, Peking University, Beijing 100871, China;

    College of Life Sciences, National Laboratory of Plant Genetic Engineering and Protein Engineering, Center of Bioinformatics, Peking University, Beijing 100871, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学现状及发展;
  • 关键词

    GPCR; signal transduction; ligands; orphan receptor; bioinformatics;

    机译：GPCR;信号转导;配体;孤儿受体;生物信息学;

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