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Phylogeny of SARS-CoV as inferred from complete genome comparison

机译：从完整的基因组比较中推断出SARS-CoV的系统发育

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SARS-CoV, as the pathogeny of severe acute respiratory syndrome (SARS), is a mystery that the origin of the virus is still unknown even a few isolates of the virus were completely sequenced. To explore the genesis of SARS-CoV, the FDOD method previously developed by us was applied to comparing complete genomes from 12 SARS-CoV isolates to those from 12 previously identified coronaviruses and an unrooted phylogenetic tree was constructed. Our results show that all SARS-CoV isolates were clustered into a clique and previously identified coronaviruses formed the other clique. Meanwhile, the three groups of coronaviruses depart from each other clearly in our tree that is consistent with the results of prevenient papers. Differently, from the topology of the phylogenetic tree we found that SARS-CoV is more close to group 1 within genus coronavirus. The topology map also shows that the 12 SARS-CoV isolates may be divided into two groups determined by the association with the SARS-CoV from the Hotel M in Hong Kong that may give some information about the infectious relationship of the SARS.
机译：作为严重急性呼吸系统综合症（SARS）的病原体，SARS-CoV的神秘之处在于，即使对几种分离的病毒进行了完整的测序，病毒的来源仍然未知。为了探索SARS-CoV的起源，我们先前开发的FDOD方法用于比较12种SARS-CoV分离株与12种先前鉴定的冠状病毒的完整基因组，并构建了无根的系统发育树。我们的结果表明，所有SARS-CoV分离株均聚集成一个集团，先前鉴定出的冠状病毒形成了另一个集团。同时，三组冠状病毒在我们的树中彼此明显分开，这与先前的论文结果一致。从系统发育树的拓扑结构不同，我们发现SARS-CoV更接近冠状病毒属的第1组。拓扑图还显示，通过与香港M酒店的SARS-CoV关联确定的12个SARS-CoV分离株可以分为两组，这可以提供一些有关SARS传染关系的信息。

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