'Protein-only' or 'virino' in prion diseases?

YANG Chiming (Chi Ming Yang); CHEN Yi

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'Protein-only' or 'virino' in prion diseases?

机译：在病毒疾病中是“仅蛋白质”还是“病毒”？

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60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are briefly but critically reviewed. Instead of providing a comprehensive coverage of the research history, attentions in this view are drawn toward both the major breakthrough in the advancement of protein-only hypothesis, and the puzzle why this hypothesis has not been fully accepted.

机译：长达60年的病毒和瘙痒病研究导致人们在理解具有诱人特征的传染性神经退行性疾病的未知病因方面陷入了两难境地。对but病毒研究的当前进展和困境进行了简要但严格的评述。这种观点并没有全面介绍研究历史，而是将注意力转向了仅蛋白质假说发展的重大突破，以及为什么这个假说未被完全接受的难题。

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来源
《Chinese science bulletin》 |2000年第3期|p.285-288|共4页
作者
YANG Chiming (Chi Ming Yang); CHEN Yi;
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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
prions; mad cow disease; neurodegenerative disorder;

机译：ions病毒;疯牛病;神经退行性疾病;

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1. A complete catalog of wild-type Sup35 prion variants and their protein-only propagation [J] . Huang Yu-Wen, King Chih-Yen Current Genetics: Eukaryotes with Emphasis on Yeasts, Fungi, Mitochondria, Plastids . 2020,第1期

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2. Potential roles for prions and protein-only inheritance in cancer [J] . H. Antony, A. P. Wiegmans, M. Q. Wei, Cancer and Metastasis Reviews . 2012,第1a2期

机译：ions病毒和仅蛋白质遗传在癌症中的潜在作用
3. Hsp104 drives "protein-only" positive selection of sup35 prion strains encoding strong [PSI~+] [J] . Desantis M.E., Shorter J. Chemistry & biology . 2012,第11期

机译：Hsp104驱动编码强[PSI〜+]的sup35 pr病毒菌株的“仅蛋白质”阳性选择
4. Role of Prion Protein Anchoring in Pathogenesis of Prion Diseases [C] . B. Chesebro Annual Meeting of the American Society for Veterinary Clinical Pathology . 2007

机译：朊蛋白锚定在朊病毒疾病发病机制中的作用
5. The Retinal Immune Response to Injury and Protein Misfolding: Insights from Models of Traumatic Brain Injury, Parkinson’s Disease, and Prion Disease [D] . Mammadova, Najiba 2019

机译：视网膜对损伤和蛋白质错误折叠的免疫反应：创伤性脑损伤，帕金森氏病和Pri病毒病模型的启示
6. Prion disease and the ‘protein-only hypothesis’ [O] . Jiyan Ma, Fei Wang -1

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7. Beyond the protein-only hypothesis: A novel mineral-lipid hypothesis in prion and protein-misfolding disease [O] . Kavitha Reddy 2017

机译：除了唯一的蛋白质假设之外：朊病毒和蛋白质错误繁殖疾病中的新型矿物质假设

'Protein-only' or 'virino' in prion diseases?

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