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首页> 外文期刊>Chinese science bulletin >Immunohistochemical localization of dopamine and norepinephrine receptors in human early placental villi
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Immunohistochemical localization of dopamine and norepinephrine receptors in human early placental villi

机译：人早期胎盘绒毛中多巴胺和去甲肾上腺素受体的免疫组织化学定位

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摘要

Evidence so far accumulated suggests that the human early placenta can be considered as a complicated neuroendocrine organ. Our previous reports have demonstrated that the human early placenta presents not only a variety of neuropeptides but also neurotrans-mitters such as 5-hydroxytryptamine (5-HT), dopamine (DA) and norepinephrine (NE). It has been shown that these neurotransmitters in human placenta may play an important role in the process of blastocyst implantation and maintenance of normal pregnancy. As far as we are aware, no information concerning the DA and/or NE receptors localized in the human early placental villi is available in literature. Recently we have developed anti-idiotypic polyclonal antiserum, previously found to bind to DA orNE repeaters respectively, specifically to the receptors of DA or NE. The present work studies the distribution of immunohistochemical reactivities of DA or NE receptors in the human early placental villi by using DA or NE anti-idiotypic polyclonal antibody as receptor probes, which will provide direct morphological evidence for further understanding their functions and mechanisms in human placenta.
机译：迄今为止积累的证据表明，人类早期胎盘可以被认为是复杂的神经内分泌器官。我们以前的报道表明，人类早期胎盘不仅呈现多种神经肽，还呈现神经递质，例如5-羟色胺（5-HT），多巴胺（DA）和去甲肾上腺素（NE）。已经表明，人胎盘中的这些神经递质可能在胚泡着床和维持正常妊娠的过程中起重要作用。据我们所知，文献中没有关于定位在人类早期胎盘绒毛中的DA和/或NE受体的信息。最近，我们开发了抗独特型多克隆抗血清，先前发现它们分别与DA或NE重复子结合，特别是与DA或NE的受体结合。本研究通过使用DA或NE抗独特型多克隆抗体作为受体探针研究DA或NE受体在人早期胎盘绒毛中的免疫组织化学反应性分布，这将为进一步了解其在人胎盘中的功能和机制提供直接的形态学证据。 。

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