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首页> 外文期刊>Clinical Journal of Gastroenterology >Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis
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Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis

机译：聚乙二醇干扰素联合利巴韦林联合皮质类固醇治疗丙型肝炎合并自身免疫性肝炎2例疗效观察

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摘要

The treatment strategy for cases of combined autoimmune hepatitis (AIH) and chronic hepatitis C (CHC) has not yet been established. A 47-year-old woman and a 53-year-old-woman were hospitalized for treatment of CHC. Ultrasonography and histological findings revealed that their liver was not cirrhotic but did have chronic damage. The histological findings of both patients were suggestive of AIH. The patients were systematically treated with pegylated interferon-alpha 2b plus ribavirin which was preceded by and combined with corticosteroid (CS), and showed sustained virological responses and normal liver function. Although these two patients with combined AIH and CHC were successfully treated with this regimen, careful attention to exacerbation of hepatic inflammation is needed because hepatitis C viral load was increased due to immunosuppression during CS treatment.
机译：尚未建立针对自身免疫性肝炎（AIH）和慢性丙型肝炎（CHC）合并症的治疗策略。一名47岁的妇女和一名53岁的妇女因CHC住院治疗。超声检查和组织学检查发现，他们的肝脏不是肝硬化的，但确实具有慢性损伤。两名患者的组织学发现均提示AIH。患者接受了聚乙二醇化干扰素-α2b联合利巴韦林的系统治疗，该治疗先于皮质类固醇（CS）并与之结合，表现出持续的病毒学应答和正常的肝功能。尽管使用该方案成功治疗了这两名合并AIH和CHC的患者，但仍需要特别注意肝炎症的恶化，因为在CS治疗期间丙肝病毒载量由于免疫抑制而增加。

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