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首页> 外文期刊>Coordination chemistry reviews >Salan vs. salen metal complexes in catalysis and medicinal applications: Virtues and pitfalls
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Salan vs. salen metal complexes in catalysis and medicinal applications: Virtues and pitfalls

机译：催化和医学应用中的Salan vs. Salen金属络合物：美德和陷阱

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Salen complexes are widely employed in catalysis and biomedical science and chiral salen complexes are among the most important catalysts for asymmetric synthesis. Their reduced counterparts, containing two N-amine donor atoms instead of N-imines, often designated by salan compounds, yield much more stable complexes and M(salan) systems present many advantages regarding the sustainability of the catalytic processes and their use as anti-cancer drugs. Although being more easily recovered than M(salen) compounds, M(salan) are much more flexible molecules and it is often not easy to control their selectivity in catalytic reactions. In contrast, some salan compounds are cytotoxic and their metal complexes are much more hydrolytically stable than the corresponding M(salen)'s making them potentially more effective and adequate compounds both in vitro and in vivo. It is, thus, feasible that in the near future this type of coordination compounds will yield therapeutic drugs able to treat cancers resistant to Pt-based drugs. (C) 2019 Published by Elsevier B.V.
机译：Salen配合物广泛用于催化和生物医学，手性的Salen配合物是不对称合成的最重要催化剂。它们的还原对应物包含两个N-胺供体原子而不是N-亚胺（通常由Salan化合物指定），可生成更加稳定的络合物，并且M（salan）系统在催化过程的可持续性及其用作抗-芳烃方面具有许多优势。癌症药物。尽管比M（salen）化合物更容易回收，但M（salan）是更具柔韧性的分子，在催化反应中控制其选择性通常不容易。相反，某些salan化合物具有细胞毒性，并且它们的金属配合物比相应的M（salen）具有更高的水解稳定性，从而使其在体外和体内都可能更有效和更合适。因此，在不久的将来这种类型的配位化合物将产生能够治疗对基于Pt的药物具有抗性的癌症的治疗药物是可行的。 （C）2019由Elsevier B.V.发布

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