...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Coordination chemistry reviews >Organic fluorescent probes for detecting mitochondrial membrane potential
【24h】

Organic fluorescent probes for detecting mitochondrial membrane potential

机译：用于检测线粒体膜电位的有机荧光探针

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mitochondrial membrane potential (MMP), as a key indicator of mitochondrial function, can reflect the cellular health status. The dysfunction of MMP, even the subtle unusual changes, can greatly affect the intracellular bioactivities, causing various diseases, such as keratitis, diabetes, Alzheimer's disease and even cancer. Thus, detecting the variation of MMP has great significance for biological research and medical diagnosis. Due to the advantages of real-time and in situ monitoring, a variety of organic fluorescent probes have been developed in recent years for the detection of MMP. However, this interesting and frontier topic has not been reviewed so far. In this review, we will focus on several kinds of recent organic fluorescent probes that have provided insights into MMP detection, including design concepts, responding mechanisms and applications of the representative examples. In addition, there are still some shortcomings and limitations of existing fluorescent probes on MMP detection, such as susceptible to interference, unquantifiable detection, and lack of clinical application. This critical review may promote the development of more robust MMP fluorescent probes, providing more powerful tools for researching basic biology to improve cancer diagnoses and treatments in clinics in the future. (C) 2020 Elsevier B.V. All rights reserved.
机译：线粒体膜电位（MMP），作为线粒体功能的关键指标，可以反映细胞健康状况。 MMP的功能障碍，即使是微妙的异常变化，也可以大大影响细胞内生物活化，导致各种疾病，如角膜炎，糖尿病，阿尔茨海默病甚至癌症。因此，检测MMP的变异对于生物学研究和医学诊断具有重要意义。由于实时和原位监测的优点，近年来近年来探测了各种有机荧光探针以检测MMP。但是，到目前为止，这种有趣和前沿主题尚未审查。在本次审查中，我们将专注于几种最近的有机荧光探针，这些荧光探针已经为MMP检测提供了见解，包括设计概念，响应机制和代表性示例的应用。此外，仍然存在对MMP检测的现有荧光探针的一些缺点和局限性，例如易受干扰，无关检测和缺乏临床应用。这次批判性审查可以促进更强大的MMP荧光探针的发展，为研究基本生物学提供更强大的工具，以改善未来诊所的癌症诊断和治疗。 （c）2020 Elsevier B.v.保留所有权利。

著录项

  • 来源
    《Coordination chemistry reviews》 |2020年第10期|213419.1-213419.15|共15页
  • 作者

    Li Xuechen; Zhao Yuping; Yin Junling; Lin Weiying;

  • 作者单位

    Qilu Univ Technol Shandong Acad Sci Sch Chem & Pharmaceut Engn Daxue Rd 3501 Jinan 250353 Peoples R China;

    Guangxi Univ Inst Opt Mat & Chem Biol Sch Chem & Chem Engn Nanning 530004 Peoples R China;

    Jinan Univ Inst Fluorescent Probes Biol Imaging Sch Chem & Chem Engn Sch Mat Sci & Engn Jinan 250022 Shandong Peoples R China;

    Guangxi Univ Inst Opt Mat & Chem Biol Sch Chem & Chem Engn Nanning 530004 Peoples R China|Jinan Univ Inst Fluorescent Probes Biol Imaging Sch Chem & Chem Engn Sch Mat Sci & Engn Jinan 250022 Shandong Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Mitochondrial membrane potential; Fluorescent probe; Mitochondria function; Cell status; Bioimaging;

    机译：线粒体膜势;荧光探针;线粒体功能;细胞状态;生物分析;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号